Phytic acid derived bioactive CaO-P2O5-SiO2 gel-glasses
Phytic acid derived bioactive CaO-P2O5-SiO2 gel-glasses
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DOI：
10.1007/s10856-011-4464-7
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发表时间：
2011-12-01
影响因子：
3.7
通讯作者：
Qiu, Dong
中科院分区：
文献类型：
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作者：
Li, Ailing;Qiu, Dong
探索了以植酸为前驱体采用溶胶-凝胶法合成CaO-P2O5-SiO2玻璃的可能性，并建立了拟三元相图。结果表明，与其他磷前体或熔融淬火方法相比，可以制备更广泛成分的凝胶玻璃。此外，植酸被发现有助于钙融入玻璃网络。对上述凝胶玻璃进行了模拟体液（SBF）体外测试，发现它们在更广泛的成分范围内具有生物活性，特别是在高磷酸盐含量下，从而使人们能够通过调整磷酸盐含量来设计具有不同降解速率的生物活性材料。
The possibility of using phytic acid as a precursor to synthesize CaO-P2O5-SiO2 glasses by sol-gel method has been explored and the pseudo ternary phase diagram has been established. It was shown that gel-glasses over a broader range of compositions could be prepared compared to other phosphorus precursors or melt-quenching method. Furthermore, phytic acid was found to assist calcium being incorporated into glass networks. In vitro tests in simulated body fluid (SBF) were performed on the above gel-glasses and it was found that they were bioactive over a much broader compositional range especially at high phosphate content, thus enabling one to design bioactive materials with various degradation rates by adjusting the phosphate content.