Weaker top-down modulation from the left inferior frontal gyrus in children
Weaker top-down modulation from the left inferior frontal gyrus in children
复制标题
DOI：
10.1016/j.neuroimage.2006.07.007
复制
发表时间：
2006-11-15
期刊：
影响因子：
5.7
通讯作者：
Booth, James R.
中科院分区：
文献类型：
--
作者：
Bitan, Tali;Burman, Douglas D.;Booth, James R.
先前的研究表明，前额叶区域结构和功能的发育变化可以持续整个童年和青春期。我们最近的研究结果表明，当成年人专注于所呈现的单词的正字法和语音方面时，左额叶下皮层在调节有效连通性的任务依赖转移中发挥了作用。具体来说，额叶下皮层自上而下的影响决定了从梭状回传入的词形信息是否会对参与正字法加工的顶叶区域或参与语音加工的颞叶区域产生更大的影响（Bitan， T., Booth, j.r., Choy， J., Burman, d.d., Gitelman， D.R.和Mesulam， M.-M.）。, 2005年。押韵和拼写过程中语言网络内有效连通性的变化。神经科学学报，25,5397-5403)。在目前的研究中，我们发现儿童在这个网络中表现出相同的任务依赖功能激活模式。然而，与成人相比，儿童从额下区发出的自上而下的调节影响明显较弱。因此，与儿童相比，成人的语言处理可能涉及更多自上而下的认知控制，从而减少与任务无关的信息的干扰。(c) 2006爱思唯尔公司版权所有。
Previous studies have shown that developmental changes in the structure and function of prefrontal regions can continue throughout childhood and adolescence. Our recent results suggested a role for the left inferior frontal cortex in modulating task-dependent shifts in effective connectivity when adults focus on orthographic versus phonological aspects of presented words. Specifically, the top-down influence of the inferior frontal cortex determined whether incoming word-form information from the fusiform gyrus would have a greater impact on the parietal areas involved in orthographic processing or temporal areas involved in phonological processing (Bitan, T., Booth, J.R., Choy, J., Burman, D.D., Gitelman, D.R. and Mesulam, M.-M., 2005. Shifts of Effective Connectivity within a Language Network during Rhyming and Spelling. J. Neurosci. 25, 5397-5403). In the current study, we find that children displayed an identical pattern of task-dependent functional activations within this network. In comparison to adults, however, children had significantly weaker top-down modulatory influences emanating from the inferior frontal area. Adult language processing may thus involve greater top-down cognitive control compared to children, resulting in less interference from task-irrelevant information. (c) 2006 Elsevier Inc. All rights reserved.