Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2 center dot)
Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2 center dot)
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DOI：
10.3109/10715769709097801
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发表时间：
1997-01-01
影响因子：
3.3
通讯作者：
Grootveld, M
中科院分区：
文献类型：
--
作者：
Lynch, E;Sheerin, A;Grootveld, M
一种含有稳定的自由基物种二氧化氯(ClO2)混合物的商用口腔含漱剂对唾液生物分子氧化消耗的多组分评估。用高分辨核磁共振氢谱研究了与亚氯酸盐阴离子(ClO2-)的作用。实验结果表明，二氧化氯具有较高的稳定性。和/或该制剂中存在的ClO2-影响唾液丙酮酸(生成醋酸盐和二氧化碳)的氧化脱羧基。在化学模型系统上进行的实验证实了这种口腔漱口水对丙酮酸的氧化脱羧基作用，还证明了尿酸盐、硫氰酸盐阴离子以及氨基酸半胱氨酸和蛋氨酸(导致口腔异味的挥发性硫化物的前体)被氧化消耗。对结果的生化、牙周及治疗意义进行了讨论。
A multicomponent evaluation of the oxidative consumption of salivary biomolecules by a commercially-available oral rinse preparation containing an admixture of the stable free radical species chlorine dioxide (ClO2.) with chlorite anion (ClO2-) has been investigated using high resolution H-1 NMR spectroscopy. The results obtained demonstrated that ClO2. and/or ClO2- present in this preparation effected the oxidative decarboxylation of salivary pyruvate (to acetate and CO2). Experiments conducted on chemical model systems confirmed the oxidative decarboxylation of pyruvate by this oral rinse, and also demonstrated that urate, thiocyanate anion, and the amino acids cysteine and methionine (precursors to volatile sulphur compounds responsible for oral malodour), were oxidatively consumed. The biochemical, periodontal and therapeutic significance of the results are discussed.