EDEINE .4. STRUCTURES OF ANTIBIOTIC PEPTIDES EDEINE-A1 AND EDEINE-B1
EDEINE .4. STRUCTURES OF ANTIBIOTIC PEPTIDES EDEINE-A1 AND EDEINE-B1
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DOI：
10.1021/bi00807a025
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发表时间：
1970-01-01
期刊：
影响因子：
2.9
通讯作者：
CRAIG, LC
中科院分区：
文献类型：
--
作者：
HETTINGE.TP;CRAIG, LC
托马斯P. Hettinger和莱曼C.克雷格摘要：依地因A已被证明是抗生素肽依地因Ai及其无活性异构体依地因A·的混合物。依地因B同样是活性依地因B1和非活性依地因B2的类似混合物。通过对部分酸水解得到的30个片段的分析，确定了依地酸Ai的氨基酸序列为：N-（β-酪氨酰）异丝氨酰-（α-D-）-2，3-二氨基丙酰-（α-D-）-2，6-二氨基-7-羟基壬二酰-（α-D-）-甘氨酰-NH（CH_2）_3 NH（CH_2）_4 NH_2。在edeine Bi中，片段的序列是相同的，除了亚精胺残基的末端氨基被胍基取代。乙二胺A和Bi发生可逆的分子内异构体-
Thomas P. Hettinger and Lyman C. Craig abstract: Edeine A has been shown to be a mixture of the antibiotic peptide edeine Ai and its inactive isomer, edeine A·,. Edeine B is likewise a similar mixture of active edeine Bi and inactive edeine B2. The amino acid sequence of edeine Ai, determined by examination of 30 fragments obtained by partial acid hydrolysis, is W-(/3-tyrosyl) isoseryl-(a:^-ci:)-2, 3-diaminopro-pionyl-(a-** o:)-2, 6-diamino-7-hydroxyazelayl-(—-a)-glycyl-NH (CH2) 3NH (CH2) 4NH2. In edeine Bi, the sequence of the fragments is identical, except that the terminal amino group of the spermidine residue is replaced by a guanidino group. Edeines A, and Bi undergo reversible intramolecular isomer-