Tropomyosin and the steric mechanism of muscle regulation.
Tropomyosin and the steric mechanism of muscle regulation.
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DOI：
10.1007/978-0-387-85766-4_8
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发表时间：
2008
影响因子：
--
通讯作者：
W. Lehman;R. Craig
中科院分区：
文献类型：
--
作者：
W. Lehman;R. Craig
所有肌肉的收缩都必须得到精确的调节，必要的控制系统必须能够适应生理和肌病刺激的变化。在本章中，我们概述了控制肌肉活动的空间机制的结构证据。其机制涉及钙和肌球蛋白诱导的原肌球蛋白沿着肌动蛋白为基础的细丝的位置的变化。这一过程要么阻断要么揭示肌动蛋白上的肌球蛋白横桥结合位点，从而调节细肌丝上的横桥循环、细肌丝和粗肌丝的滑动以及肌肉缩短和力的产生。
Contraction in all muscles must be precisely regulated and requisite control systems must be able to adjust to changes in physiological and myopathic stimuli. In this chapter, we outline the structural evidence for a steric mechanism that governs muscle activity. The mechanism involves calcium and myosin induced changes in the position of tropomyosin along actin-based thin filaments. This process either blocks or uncovers myosin crossbridge binding sites on actin and consequently regulates crossbridge cycling on thin filaments, the sliding of thin and thick filaments and muscle shortening and force production.