Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population.
Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population.
复制标题
中国人群雌激素受体α基因多态性与乙型肝炎相关急性肝衰竭风险
DOI：
10.1186/1471-2350-13-49
复制
发表时间：
2012-06-24
影响因子：
--
通讯作者：
Deng G
中科院分区：
文献类型：
--
作者：
Yan Z;Tan W;Dan Y;Zhao W;Deng C;Wang Y;Deng G
背景B型肝炎病毒（HBV）相关性肝病的性二态性与雌激素及其受体有关。最近的报道表明，雌激素受体α（ESR 1）的异常表达可能是肝脏疾病进展的标志，并且呈现变异ESR 1的HBV携带者具有极其侵袭性的临床过程。在这里，我们研究是否theESR 1多态性或其单倍型与HBV相关的急性肝衰竭（ALF）的风险在慢性HBV携带者在中国population.MethodsA共招募了1216无关的汉族HBV携带者在此医院为基础的病例对照研究，包括359 HBV表面抗原（HBsAg）携带者与ALF和857无症状HBsAg携带者。两个ESR 1单倍型标签多态性，c.30 T > C（rs 2077647）和c.453-397 T > C（rs 2234693），采用聚合酶链反应-限制性片段长度多态性方法进行基因分型结果我们观察到与c. 30 C等位基因相关的HBV-ALF易感性显著增加，（P = 8.65 × 10-4），c.453-397 C等位基因（5.37 × 10-4）和[c.30 C; c.453-397 C]单倍型（显性模型，P=0.0004，比值比= 1.53，95% CI 1.23 ~ 1.96）与T等位基因和[c.30 T;结论[c.30 C; c.453 - 397 C]单倍型可能是中国人群HBV相关ALF遗传易感性的危险因素。它还强调了ESR 1在人群水平上HBV相关ALF的病理生理学中的重要性。
BackgroundThe sexual dimorphism of hepatitis B virus (HBV) -related liver diseases is related with estrogen and its receptors. Recent reports indicate that abnormal expression of estrogen receptor alpha (ESR1) may be a hallmark for the progression of liver disease and HBV carriers presenting variant ESR1 have an extremely aggressive clinical course. Here we examine whether theESR1polymorphisms or its haplotypes are related to HBV-related acute liver failure (ALF) risk among chronic HBV carriers in a Chinese population.MethodsA total of 1216 unrelated Han Chinese HBV carriers were recruited in this hospital-based case–control study, including 359 HBV surface antigen (HBsAg) carriers affected with ALF and 857 asymptomatic HBsAg carriers. TwoESR1haplotype tagging polymorphisms, c.30 T > C (rs2077647) and c.453-397 T > C (rs2234693), were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.ResultsWe observed a significantly increased susceptibility to HBV-ALF associated with the c.30 C allele (P = 8.65 × 10-4), c.453-397 C allele (5.37 × 10-4) and [c.30 C; c.453-397 C] haplotype (Dominant model,P=0.0004, odds ratio = 1.53, 95% CI 1.23 ~ 1.96) compared with the T alleles and [c.30 T; c.453-397 T] haplotype of c.30 T > C and c.453-397 T > C polymorphisms, respectively.ConclusionsOur study suggests that [c.30 C; c.453-397 C] hapotype may be a risk factor for genetic susceptibility to HBV-related ALF in the Chinese population. It also emphasizes the importance of ESR1 in the pathophysiology of HBV-related ALF on the population level.