PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries
PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries
复制标题
PAPA：使用全基因组关联研究摘要识别多效性途径的灵活工具。
DOI：
10.1093/bioinformatics/btv668
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发表时间：
2016-03-15
期刊：
影响因子：
5.8
通讯作者：
Zhang, Feng
中科院分区：
文献类型：
--
作者：
Wen, Yan;Wang, Wenyu;Zhang, Feng
Pleiotropy is common in the genetic architectures of complex diseases. To the best of our knowledge, no analysis tool has been developed for identifying pleiotropic pathways using multiple genome-wide association study (GWAS) summaries by now. Here, we present PAPA, a flexible tool for pleiotropic pathway analysis utilizing GWAS summary results. The performance of PAPA was validated using publicly available GWAS summaries of body mass index and waist-hip ratio of the GIANT datasets. PAPA identified a set of pleiotropic pathways, which have been demonstrated to be involved in the development of obesity.
