Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells
Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells
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DOI：
10.1016/j.bbrc.2006.03.195
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发表时间：
2006-06-09
影响因子：
3.1
通讯作者：
Miura, Naoyuki
中科院分区：
文献类型：
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作者：
Chandra, Abhshek;Itakura, Tatsuo;Miura, Naoyuki
骨形态发生蛋白 (BMP) 拮抗剂通过与 BMP 结合来调节 BMP 的多效性作用。我们之前分离出了 Neurogenesin-1 (Ng1) 基因，发现 Ng1 蛋白诱导大脑中的神经元分化。在本研究中，我们发现Ng1在骨骼的原始细胞中表达，并研究Ng1蛋白是否抑制BMP作用以诱导C2C12成肌细胞的成骨细胞分化。有趣的是，Ng1 蛋白抑制 BMP7 诱导的碱性磷酸酶活性，但不抑制 BMP2 诱导的活性。总之，数据表明 Ng1 蛋白通过差异调节 BMP 在胚胎骨形成中发挥重要作用。 (c) 2006 Elsevier Inc. 保留所有权利。
Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously isolated the Neurogenesin-1 (Ng1) gene and found that Ng1 protein induces neuronal differentiation in the brain. In this study, we found that Ng1 was expressed in the primordial cells of the skeleton and investigated whether Ng1 protein inhibited the BMP action to induce osteoblastic differentiation in C2C12 myoblasts. Interestingly, Ng1 protein inhibited the BMP7-iriduced alkaline phosphatase activity while it did not inhibit the BMP2-induced activity. All, data suggest that Ng1 protein plays an important role in the embryonic bone formation by differentially regulating BMPs. (c) 2006 Elsevier Inc. All rights reserved.