Advances in the life cycle of Toxoplasma gondii
Advances in the life cycle of Toxoplasma gondii
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DOI：
10.1016/s0020-7519(98)00023-x
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发表时间：
1998-07-01
影响因子：
4
通讯作者：
Dubey, JP
中科院分区：
文献类型：
--
作者：
Dubey, JP
本文综述了近年来弓形虫生活史的研究进展。速殖子、缓殖子和孢子是T.刚地。人类和动物主要通过侵入性缓殖子或卵囊感染。吞食后，缓殖子和子孢子都在组织内转化为速殖子。速殖子向缓殖子和缓殖子向速殖子的转化具有生物学和临床意义，因为缓殖子对化疗不太敏感，并且缓殖子向速殖子的再活化被认为是艾滋病患者中致死性弓形虫病的原因。在目前评价T.弓形虫感染阶段喂猫是最可靠的方法。猫科动物是T.弓形虫在进入组织包囊/缓殖子后3-10天、进入卵囊后大于或等于18天、进入速殖子后大于或等于13天排出卵囊。出版社：Elsevier Science Ltd
This paper reviews recent studies on the life cycle of Toxoplasma gondii. Tachyzoites, bradyzoites, and sporozoites are the three infectious stages of T. gondii. Humans and animals become infected mainly by ingesting bradyzoites or oocysts. After ingestion, both bradyzoites and sporozoites convert to tachyzoites inside tissues. The conversion of tachyzoites to bradyzoites and bradyzoites to tachyzoites is of biological and clinical significance because bradyzoites are less susceptible to chemotherapy and reactivation of bradyzoites to tachyzoites is considered the cause of fatal toxoplasmosis in AIDS patients. Of all the methods currently available to assess stage conversion of T. gondii, feeding infective stages to cats is the most reliable method. Felidae, the definitive hosts of T. gondii excrete oocysts 3-10 days after ingesting tissue cysts/bradyzoites, greater than or equal to 18 days after ingesting oocysts, and greater than or equal to 13 days after ingesting tachyzoites. Published by Elsevier Science Ltd.