PLATELET 5-HYDROXYTRYPTAMINE ACCUMULATION IN DEPRESSIVE-ILLNESS
PLATELET 5-HYDROXYTRYPTAMINE ACCUMULATION IN DEPRESSIVE-ILLNESS
复制标题
DOI：
10.1016/0009-8981(78)90071-2
复制
发表时间：
1978-01-01
影响因子：
5
通讯作者：
WOOD, K
中科院分区：
文献类型：
--
作者：
COPPEN, A;SWADE, C;WOOD, K
采用短孵育时间和低底物浓度测定了对照组、抑郁症患者和抑郁症恢复患者血小板对5-羟色胺（5-HT）的摄取。急性抑郁症患者和抑郁症康复者的血小板膜5-羟色胺亲和力均正常。5-HT通过血小板膜的运输能力受损，在这些抑郁症患者，这种损害是独立的患者的精神状态，并讨论了与抑郁症相关的电解质和酶紊乱的光。
The uptake of 5-hydroxytryptamine (5-HT) by blood platelets from controls, depressed patients and recovered depressed patients was determined using short incubation times and low substrate concentrations. The affinity of serotonin for the platelet membrane was normal in acutely depressed and recovered depressed patients. The capacity of transport of 5-HT through the platelet membrane was impaired in these depressive patients and this impairment was independent of the psychiatric status of the patients and was discussed in the light of the electrolyte and enzyme disturbances that are associated with depressive illness.