Trauma to the skin causes recurrence of herpes simplex in the mouse.
Trauma to the skin causes recurrence of herpes simplex in the mouse.
复制标题
皮肤创伤会导致小鼠单纯疱疹复发。
DOI：
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发表时间：
1978
影响因子：
3.8
通讯作者：
D. Harbour
中科院分区：
文献类型：
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作者：
T. Hill;W. Blyth;D. Harbour
通过用玻璃纸胶带剥离最初感染的耳部，在潜伏感染单纯疱疹病毒I型的小鼠的皮肤中诱导轻度创伤。2 ~ 5天后，该部位复发性单纯疱疹。临床上通过红斑和水泡的出现以及皮肤中病毒的出现来检测。在任何一种情况下，约30%的小鼠表现出复发性疾病，增加创伤的严重程度并没有增加这一比例。然而，当每月重复剥离时，大多数动物在某些情况下发生了再活化疾病。结果进行了讨论有关的皮肤触发理论的单纯疱疹病毒的重新激活。
Mild trauma was induced in the skin of mice latently infected with herpes simplex virus type I by stripping the originally infected ear with cellophane tape. Recurrent herpes simplex developed at this site 2 to 5 days later. It was detected clinically by the development of erythema and vesicles and by the appearance of virus in the skin. On any one occasion about 30% of mice showed reactivated disease and increasing the severity of trauma did not increase this proportion. However the majority of animals developed reactivated disease on some occasions when stripping was repeated at monthly intervals. The results are discussed in relation to the skin trigger theory of reactivation of herpes simplex.