Intracerebral evoked potentials in pitch perception reveal a functional asymmetry of the human auditory cortex
Intracerebral evoked potentials in pitch perception reveal a functional asymmetry of the human auditory cortex
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DOI：
10.1111/j.1749-6632.2001.tb05728.x
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Chauvel, P
中科院分区：
文献类型：
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作者：
Liégeois-Chauvel, C;Giraud, K;Chauvel, P
在音高感知中起重要作用的一个声学特征是频率。对人类和动物大脑中频率处理的研究表明，听觉皮层是按音调组织的：低频在侧面表示，而高频在中间表示。迄今为止，人类听觉皮层在频率处理中的功能组织的研究一直局限于使用具有相对较差的空间分辨率的头皮记录的听觉诱发电位（AEP）或具有较差的时间分辨率的功能成像技术。本研究使用脑内记录的AEPs来探讨这一主题在初级和次级听觉皮层的两个半球的人类大脑。对45例成人耐药部分性癫痫患者进行了记录。在右半球，清晰的频谱组织tonotopic地图观察到不同的频率处理区域之间的明显分离。高频的AEP记录在内侧，而低频的AEP记录在外侧。然而，在左半球，这种音调组织不太明显，不同的区域参与处理一系列频率。在音调频率的处理与音高知觉的关系，半球相关的差异进行了讨论。
One acoustic feature that plays an important role in pitch perception is frequency. Studies on the processing of frequency in the human and animal brain have shown that the auditory cortex is tonotopically organized: low frequencies are represented laterally whereas high frequencies are represented medially. To date, the study of the functional organization of the human auditory cortex in the processing of frequency has been limited to the use of either scalp-recorded auditory evoked potentials (AEPs), which have relatively poor spatial resolving power, or functional imagery techniques, which have poor temporal resolving power. The present study uses intracerebrally recorded AEPs to explore this topic in the primary and secondary auditory cortices of both hemispheres of the human brain. Recordings were carried out in 45 adult patients with drug-resistant partial seizures. In the right hemisphere, clear spectrally organized tonotopic maps were observed with distinct separations between different frequency-processing regions. AEPs for high frequencies were recorded medially, whereas AEPs for low frequencies were recorded laterally. In the left hemisphere, however, this tonotopic organization was less evident, with different regions involved in the processing of a range of frequencies. The hemisphere-related difference in the processing of tonal frequency is discussed in relation to pitch perception.