Heparan sulfates and heparins:: similar compounds performing the same functions in vertebrates and invertebrates?
Heparan sulfates and heparins:: similar compounds performing the same functions in vertebrates and invertebrates?
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DOI：
10.1590/s0100-879x1999000500005
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发表时间：
1999-05-01
影响因子：
2.3
通讯作者：
Dietrich, CP
中科院分区：
文献类型：
--
作者：
Nader, HB;Chavante, SF;Dietrich, CP
综述了硫酸肝素和肝素的分布和结构。硫酸乙酰肝素是动物细胞中普遍存在的化合物，其结构在进化过程中一直保持不变，其双糖单位的相对数量表现出巨大的可变性。另一方面，肝素仅存在于动物界的少数组织和物种中，并以颗粒的形式存在于特殊细胞的细胞器内。因此，分子的分布和主要结构特征，包括其主要的双糖单元，通过进化得以保持。这些研究和其他研究提出硫酸肝素可能参与细胞-细胞识别现象和控制细胞生长，而肝素可能参与抵抗细菌和其他外来物质的防御机制。到目前为止获得的所有迹象都表明，这些分子在脊椎动物和无脊椎动物中起着相同的作用。
The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.