Normal activities of glycolytic enzymes in the fetal erythrocytes.
Normal activities of glycolytic enzymes in the fetal erythrocytes.
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胎儿红细胞中糖酵解酶的正常活动。
DOI：
10.1111/j.1365-2141.1982.tb01939.x
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发表时间：
1982
影响因子：
6.5
通讯作者：
J. White
中科院分区：
文献类型：
--
作者：
A. N. Lestas;C. Rodeck;J. White
取孕17~24周的24例胎儿，用直视胎儿镜取纯胎儿血。用已建立的技术分析了红细胞中14种糖酵解酶的活性，以找出该胎龄的正常活性范围。该结果与24名正常成人的结果以及公布的新生儿血液值进行了比较。胎儿红细胞中大多数酶的活性较高，且相对活性模式不同于成人或新生儿血液。其范围较窄，可作为红细胞酶病产前诊断的参考值。此外，糖酵解酶的活性将为了解胎儿的红细胞代谢提供基础。
Pure fetal blood was obtained by direct-vision fetoscopy from 24 fetuses at 17-24 weeks' gestation. The activities of 14 glycolytic enzymes in the erythrocytes were analysed by established techniques to find the normal ranges of activity for this gestational age. The results were compared with those obtained from 24 normal adults and with published values on neonatal blood. The activities of most enzymes in fetal erythrocytes were found to be higher and the relative pattern of activity different from those of adult or neonatal blood. The ranges were relatively narrow and can serve as reference values for the prenatal diagnosis of erythrocytic enzymopathies. Also, the activities of the glycolytic enzymes will provide a basis for the understanding of erythrocyte metabolism in the fetus.