Significant increase in maternal plasma leptin concentration in induced delivery: A possible contribution of pro-inflammatory cytokines to placental leptin secretion
Significant increase in maternal plasma leptin concentration in induced delivery: A possible contribution of pro-inflammatory cytokines to placental leptin secretion
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DOI：
10.1507/endocrj.51.177
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发表时间：
2004-04-01
影响因子：
2
通讯作者：
Fujii, S
中科院分区：
文献类型：
--
作者：
Nuamah, MA;Yura, S;Fujii, S
孕妇血浆瘦素浓度在妊娠期间显著升高。然而，它在妊娠中的作用，特别是在分娩中，尚未完全阐明。我们测量了妊娠妇女在引产过程中、自然阴道分娩后和足月剖宫产后的血浆瘦素浓度。我们还研究了从足月胎盘组织和BeWo细胞（滋养层细胞系）分泌瘦素的调节。临产时血浆瘦素浓度（58.9 ± 9.2 ng/ml）较引产前（37.5 ± 5.8 ng/ml）显著升高（P
Maternal plasma leptin concentration is significantly increased during pregnancy. However, its roles in pregnancy, especially in labor, have not been fully clarified. We measured plasma leptin concentrations in pregnant women during the course of induced labor, just after spontaneous vaginal delivery and Cesarean section at term. We also studied the regulation of leptin secretion from term placental tissue and BeWo cells, a trophoblastic cell-line. Plasma leptin concentrations increased significantly during labor (58.9 +/- 9.2 ng/ml) compared to those before labor induction (37.5 +/- 5.8 ng/ml, P