Can rats control previously acquired spatial information? Evidence of “directed forgetting” phenomenon in delay-interposed radial maze behavior
Can rats control previously acquired spatial information? Evidence of “directed forgetting” phenomenon in delay-interposed radial maze behavior
复制标题
大鼠能否控制先前获得的空间信息？延迟插入径向迷宫行为中“定向遗忘”现象的证据
DOI：
10.1016/j.bbr.2013.03.030
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
M.
中科院分区：
文献类型：
--
作者：
Kaku;M.
“定向遗忘”是一种方法和现象，用于研究生物体是否可以通过指令来控制记忆，以忘记和记住。采用改良的放射状迷宫任务研究大鼠定向遗忘现象。在延迟插入的径向迷宫任务中，在四个正确的选择之后延迟120分钟，在此期间，大鼠被放置在白色或黑色盒子中，这表明延迟后是否需要下半场的表现（记住（R）-试验），或者不需要（忘记（F）-试验）。R-和F-试验各重复5次，然后进行“探测测试”，在该测试中进行下半场的表现，尽管F-线索在延迟期间呈现。大鼠在探测试验中比在R试验中犯了更多的错误。这些结果证明了大鼠在径向迷宫任务中的“定向遗忘”现象，并表明大鼠确实可以控制先前获得的空间信息，即使是在长保留间隔的情况下。尽管“遗忘线索”的呈现影响大鼠信息处理的机制尚不清楚，但包括内侧前额叶皮层和海马CA 3区在内的几个大脑区域在“记忆”线索试验中比在“遗忘”线索试验中更活跃，这表明这些区域可能与研究中展示的空间信息的“定向遗忘”现象有关。
“Directed forgetting” is a method and a phenomenon used to investigate whether organisms can control memory with instructions to forget, and to remember. We examined directed forgetting phenomenon in rats, using a modified radial maze task. In the delay-interposed radial maze task, a 120-min delay followed four correct choices, during which rats were placed in either a white or black box, that signaled whether a second-half performance will be required (remember (R)-trial), or not (forget (F)-trial) after the delay. R- and F-trials were repeated 5 times each, followed by a “probe test,” in which the second-half performance was conducted, although the F-cue was presented during the delay period. Rats made more errors in the probe test than in the R-trial. These results demonstrate the “directed forgetting” phenomenon in a radial maze task in rats, and suggest that rats can indeed control previously acquired spatial information, even situations with a long retention interval interposed. Although the mechanism by which presentation of the “forget-cue” influences rats’ information processing remains unclear, several brain regions, including the medial prefrontal cortex and the hippocampal CA3 area, were shown to be more activated in the “remember”-cued trial than in the “forget”-cued trial, suggesting that these areas are potentially related to the “directed forgetting” phenomenon of spatial information demonstrated in the study.