Targeted Cortical Manipulation of Auditory Perception
Targeted Cortical Manipulation of Auditory Perception
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DOI：
10.1016/j.neuron.2019.09.043
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发表时间：
2019-12-18
期刊：
影响因子：
16.2
通讯作者：
Bathellier, Brice
中科院分区：
文献类型：
--
作者：
Ceballo, Sebastian;Piwkowska, Zuzanna;Bathellier, Brice
通过直接激活大脑皮层的神经集合来驱动感知是理解听觉感知的神经编码和发展中枢感觉康复方法的必要步骤。在这里，在小鼠的听觉辨别任务中使用光遗传学操作，我们表明听觉皮层可以被简单的声音识别的粗糙通路短路。然而，当感觉决策变得更加复杂，涉及信息的时间整合时，听觉皮层活动是声音辨别所必需的，特定皮层集合的定向激活会改变感知决策，正如我们对皮层代码的读出所预测的那样。因此，听觉皮层的表征有助于声音的歧视，从平行的路线细化决定。
Driving perception by direct activation of neural ensembles in cortex is a necessary step for achieving a causal understanding of the neural code for auditory perception and developing central sensory rehabilitation methods. Here, using optogenetic manipulations during an auditory discrimination task in mice, we show that auditory cortex can be short-circuited by coarser pathways for simple sound identification. Yet when the sensory decision becomes more complex, involving temporal integration of information, auditory cortex activity is required for sound discrimination and targeted activation of specific cortical ensembles changes perceptual decisions, as predicted by our readout of the cortical code. Hence, auditory cortex representations contribute to sound discriminations by refining decisions from parallel routes.