Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome
Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome
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DOI：
10.1002/hon.953
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发表时间：
2011-03-01
影响因子：
3.3
通讯作者：
Bertoni, Francesco
中科院分区：
文献类型：
--
作者：
Chigrinova, Ekaterina;Mian, Michael;Bertoni, Francesco
弥漫性大b细胞淋巴瘤（DLBCL）的骨髓（BM）累及与原发肿瘤的形态学不一致。一致性脑脊膜浸润与CHOP治疗患者预后较差有关。为了评估导致骨髓转移累及DLBCL的肿瘤相关因素，我们对以下数据进行了综合分析：1)高密度全基因组单核苷酸多态性（snp）阵列获得的基因组图谱；2)免疫形态学和3)133例接受R-CHOP统一治疗的患者的临床数据。133例中27例（20%）发现脑脊膜瘤浸润；27例中有18例（67%）是一致的。一致性浸润对OS、PFS和DFS均有负性影响，并与较高的血清LDH、较低的CR和较高的PD率相关。BM+和BM- dlbcl与细胞来源无关。与BM-病例相比，BM+ DLBCL没有7q增益。版权所有John Wiley & Sons， Ltd。
Bone marrow ( BM) involvement in diffuse large B-cell lymphoma (DLBCL) can be morphologically discordant from the primary tumor. Concordant BM infiltration has been shown associated with a poorer outcome in patients treated with CHOP. In order to evaluate tumor-related factors leading to BM involvement in DLBCL, we performed an integrated analysis of i) genomic profiles obtained with a high-density genome wide SNP-based arrays ii) immunomorphological and iii) clinical data from 133 patients uniformly treated with R-CHOP. BM infiltration was found in 27 of 133 ( 20%) cases; and it was concordant in 18/27 (67%) cases. Concordant infiltration, but not discordant, influenced negatively OS, PFS and DFS and was associated with higher serum LDH, lower CR and higher PD rates. No association with cell of origin was found between BM+ and BM-DLBCL. As compared with BM- cases, BM+ DLBCL showed absence of 7q gain. Copyright (C) 2010 John Wiley & Sons, Ltd.