Salivary and Serum Interleukin-18 in Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population
Salivary and Serum Interleukin-18 in Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population
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DOI：
10.1007/s10753-011-9327-3
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发表时间：
2011-04
期刊：
影响因子：
5.1
通讯作者：
Yuanyuan Zhang;Wenzhao Liu;Songtao Zhang;H. Dan;Rui Lu;Fang Wang;Jing Wang;Min Zhou;X. Zeng;Mei Lin;Qianming Chen;Yu Zhou-
中科院分区：
文献类型：
--
作者：
Yuanyuan Zhang;Wenzhao Liu;Songtao Zhang;H. Dan;Rui Lu;Fang Wang;Jing Wang;Min Zhou;X. Zeng;Mei Lin;Qianming Chen;Yu Zhou-
本研究旨在探讨细胞因子白细胞介素（IL-18）在口腔扁平苔藓（OLP）中的促炎作用，为OLP的早期诊断提供可靠的指标。103例中国OLP患者参加了这项研究，48例年龄和性别匹配的对照组。采用酶联免疫吸附试验检测血清和唾液中IL-18的浓度。蛋白质含量以皮克/毫升表示。与对照组相比，OLP患者血清中IL-18表达水平较高OLP组为21.32 ± 8.26 pg/mL，对照组为12.29 ± 5.11 pg/mL，P< 0.05 OLP = 20.12 ± 5.78 pg/mL，对照组= 15.60 ± 4.17 pg/mL，P< 0.05。在OLP患者中，血清和唾液IL-18升高，与疾病的严重程度相关。这些发现可能被认为是改善炎症细胞因子的预测或预后价值的OLP，也设计可能的新的治疗方法。
The purpose of this study was to investigate the potential pro-inflammatory role of the cytokine interleukin (IL-18) in oral lichen planus (OLP) so as to provide a reliable and early indicator for the diagnosis of OLP. One hundred three ethnic Chinese patients with OLP were enrolled in this study, as were 48 age- and sex-matched controls. IL-18 concentrations in serum and saliva were screened by enzyme-linked immunosorbent assay. The protein content was expressed as picograms per milliliter. OLP patients showed a high-level of IL-18 expression profile in serum compared with the control group (OLP = 21.32 ± 8.26 pg/mL, control = 12.29 ± 5.11 pg/mL,P< 0.05), and the saliva partner had significantly higher concentrations of IL-18 compared to the control (OLP = 20.12 ± 5.78 pg/mL, control = 15.60 ± 4.17 pg/mL,P< 0.05). In patients with OLP, serum and salivary IL-18 are elevated, correlating with the severity of illness. These findings may be considered to improve the predictive or prognostic values of inflammatory cytokines for OLP and also to design possible novel therapeutic approaches.