Effect of 3-methylcholanthrene on the development of aortic lesions in mice.
Effect of 3-methylcholanthrene on the development of aortic lesions in mice.
复制标题
3-甲基胆蒽对小鼠主动脉病变发展的影响。
作者：
B. Paigen;M. Havens;A. Morrow
The effect of a carcinogen, 3-methylcholanthrene (3-MC), on the formation and growth of atherosclerotic lesions in mice was examined.将 3-MC 的剂量从 15 微克/千克增加到 1500 微克/千克，会增加 AKXL-38a 小鼠主动脉中脂质染色病变的数量和大小，这些小鼠喂食致动脉粥样硬化饮食 8 周。对于用 3-MC（150 微克/千克）治疗的动物，每只小鼠的病变数量为 0.85 +/- 0.19 (SE)，而给予溶剂而非 3-MC 的动物为 0.10 +/- 0.10 病变/小鼠。 The progression of lesions over time from 5 to 18 weeks showed that 3-MC-treated mice also differed from controls in the size of lesions.在致动脉粥样化饮食18周时，根据病变数量和每个病变的大小（以1至4分表示），每只小鼠的总得分对于3-MC治疗的动物为4.31+/-0.71，对于给予溶剂的动物为2.67+/-0.74。即使在致动脉粥样硬化饮食的第一周内给予全部剂量的 3-MC，也可以在 18 周时观察到 3-MC 治疗的效果。 These experiments do not distinguish whether 3-MC affects atherosclerotic lesions by acting as a mutagen or by some other mechanism.给出了在小鼠中产生病变且死亡率不高的致动脉粥样化饮食的组成，以及评估病变形成的不同方法的比较。
The effect of a carcinogen, 3-methylcholanthrene (3-MC), on the formation and growth of atherosclerotic lesions in mice was examined. Increasing doses of 3-MC from 15 to 1500 micrograms/kg increased the number and size of lipid-staining lesions in the aorta of AKXL-38a mice that were fed an atherogenic diet for 8 weeks. The number of lesions per mouse was 0.85 +/- 0.19 (SE) for animals treated with 3-MC (150 micrograms/kg) compared to 0.10 +/- 0.10 lesions/mouse for animals given solvent rather than 3-MC. The progression of lesions over time from 5 to 18 weeks showed that 3-MC-treated mice also differed from controls in the size of lesions. The total score per mouse at 18 weeks of atherogenic diet, based on the number of lesions and the size of each lesion, indicated by a score of 1 to 4, was 4.31 +/- 0.71 for 3-MC-treated animals and 2.67 +/- 0.74 for animals given solvent. The effect of 3-MC treatment could be observed at 18 weeks even though the entire dose of 3-MC was given during the first week on the atherogenic diet. These experiments do not distinguish whether 3-MC affects atherosclerotic lesions by acting as a mutagen or by some other mechanism. The composition of an atherogenic diet that produces lesions in mice without high mortality is given as well as a comparison of different methods of evaluating lesion formation.
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小鼠脂质运输的遗传控制。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
LeBoeuf,RC;Puppione,DL;Schumaker,VN;Lusis,AJ
通讯作者：
Lusis,AJ
小鼠脂质运输的遗传控制。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Lusis,AJ;Taylor,BA;Wangenstein,RW;LeBoeuf,RC
通讯作者：
LeBoeuf,RC
皮肤疤痕的克隆特征及其对动脉粥样硬化形成的影响。
DOI：
--
发表时间：
1981
期刊：
The American journal of pathology
影响因子：
--
作者：
Pearson,TA;Dillman,JM;Solez,K;Heptinstall,RH
通讯作者：
Heptinstall,RH
长期接触 7,12-二甲基苯并（a）蒽后，主动脉病变的大小呈剂量依赖性增加。
影响因子：
11.2
作者：
Penn,A;Batastini,G;Soloman,J;Burns,F;Albert,R
通讯作者：
Albert,R