Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus
Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus
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DOI：
10.1016/j.cell.2020.01.014
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发表时间：
2020-02-06
期刊：
影响因子：
64.5
通讯作者：
Frank, Loren M.
中科院分区：
文献类型：
--
作者：
Kay, Kenneth;Chung, Jason E.;Frank, Loren M.
想象力、计划和决策等认知能力需要表现假设经验的能力。至关重要的是，动物在自然环境中的行为意味着，随着外部事件的不断展开，大脑不仅可以快速地代表假想的未来经验，而且可以随着时间的推移而不断地表现出来。为了确定这是如何可能的，我们记录了在具有多条空间路径的迷宫中航行的大鼠海马区的神经活动。我们发现，神经活动在8赫兹的恒定交替中编码两种可能的未来情景(两条即将到来的迷宫路径)：每一种情景类似于125毫秒的周期。此外，我们发现，循环的潜在动力(包括周期间和周期内的动力)概括在定性不同的代表性关联(位置和方向)上。值得注意的是，骑车发生在各种移动行为中，包括在跑步期间。这些发现确定了一个一般的动态过程，能够快速而持续地呈现假设经验，包括多个可能的未来的经验。
Cognitive faculties such as imagination, planning, and decision-making entail the ability to represent hypothetical experience. Crucially, animal behavior in natural settings implies that the brain can represent hypothetical future experience not only quickly but also constantly over time, as external events continually unfold. To determine how this is possible, we recorded neural activity in the hippocampus of rats navigating a maze with multiple spatial paths. We found neural activity encoding two possible future scenarios (two upcoming maze paths) in constant alternation at 8 Hz: one scenario per similar to 125-ms cycle. Further, we found that the underlying dynamics of cycling (both inter- and intra-cycle dynamics) generalized across qualitatively different representational correlates (location and direction). Notably, cycling occurred across moving behaviors, including during running. These findings identify a general dynamic process capable of quickly and continually representing hypothetical experience, including that of multiple possible futures.