Current clinical state of type 1 diabetes in Saitama prefecture
Current clinical state of type 1 diabetes in Saitama prefecture
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DOI：
10.1007/s13340-021-00557-8
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发表时间：
2021-11-01
影响因子：
2.2
通讯作者：
Shimada, Akira
中科院分区：
文献类型：
--
作者：
Oikawa, Yoichi;Hashimoto, Koshi;Shimada, Akira
在日本，1型糖尿病（T1 D）的流行病学研究主要集中在儿童期。同时，关于青少年和成人T1 D的临床特征的信息有限。因此，我们的目的是调查他们目前在日本东京附近的琦玉县的临床状态。材料和方法我们进行了一项横断面、以医院为基础的多中心研究。八个机构参与了这项研究，所有这些机构都治疗了相对大量的T1 D患者。我们确定了1241例16岁或以上的T1 D患者：814例急性发作型T1 D（AT 1D），362例缓慢进展型胰岛素依赖型糖尿病（SPIDDM），65例暴发型T1 D（FT 1D）。根据患者的医疗记录，研究了各种临床参数和并发症。结果1241例患者中，女性739例（59.5%）。在所有患者中，中位年龄、发病年龄和疾病持续时间分别为51、38和13岁。患者的BMI中位数为22.6 kg/m（2），26.1%肥胖，这证实了之前的全国性调查。此外，HbA 1c的中位数为7.8%，与之前的全国性调查相似。在AT 1D、SPIDDM和FT 1D患者中，分别有85.6%、72.1%和81.5%的患者每天多次注射胰岛素，而10.3%、2.2%和18.5%的患者接受持续皮下胰岛素输注。视网膜病变、肾病和神经病变的比例分别为26.3%、20.8%和21.5%。结论琦玉T1 D患者的血糖控制与之前全国调查中观察到的结果相当。此外，大约四分之一的T1 D患者患有肥胖症。未来的研究应该解决我们的研究结果是否反映了整个日本的情况。
Introduction In Japan, epidemiological studies on type 1 diabetes (T1D) have mainly focused on the disease in childhood. Meanwhile, limited information is available regarding the clinical features of adolescent and adult T1D. Therefore, we aimed to investigate their current clinical state in Saitama prefecture near Tokyo, Japan. Materials and methods We conducted a cross-sectional, hospital-based, multicenter study. Eight institutions participated in the study, all of which treated relatively large numbers of T1D patients. We identified 1241 T1D patients aged 16 or over: 814 with acute-onset T1D (AT1D), 362 with slowly progressive insulin-dependent diabetes mellitus (SPIDDM), and 65 with fulminant T1D (FT1D). Based on the patient's medical records, various clinical parameters and complications were investigated. Results Of 1241 patients, 739 (59.5%) were females. Among all patients, the median age, onset age, and disease duration were 51, 38, and 13 years, respectively. The patients had a median BMI of 22.6 kg/m(2), and 26.1% were obese, corroborating previous nationwide surveys. Moreover, the median HbA1c was 7.8%, similar to previous nationwide surveys. Among patients with AT1D, SPIDDM, and FT1D, 85.6%, 72.1%, and 81.5% carried out multiple daily insulin injection, respectively, while 10.3%, 2.2%, and 18.5% were subject to continuous subcutaneous insulin infusion. The proportions of retinopathy, nephropathy, and neuropathy were 26.3%, 20.8%, and 21.5%. Conclusions The glycemic control in T1D patients in Saitama was equivalent to that observed in previous nationwide surveys. Moreover, approximately one-quarter of T1D patients had obesity. Future studies should address whether our findings reflect those throughout Japan.