RISK-FACTORS FOR INFECTION WITH ECHINOCOCCUS-MULTILOCULARIS IN ALASKA
RISK-FACTORS FOR INFECTION WITH ECHINOCOCCUS-MULTILOCULARIS IN ALASKA
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DOI：
10.4269/ajtmh.1988.38.380
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发表时间：
1988-03-01
影响因子：
3.3
通讯作者：
LANIER, A
中科院分区：
文献类型：
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作者：
STEHRGREEN, JK;STEHRGREEN, PA;LANIER, A
我们对来自阿拉斯加西北海岸的19名患有泡型包虫病的爱斯基摩患者进行了研究，以寻找感染多房棘球绦虫的风险因素。每个病例患者都按照年龄和性别与2名无相关关系的对照者进行匹配，这些对照者没有多房棘球绦虫感染的临床或血清学证据，且居住在三个泡型包虫病流行的村庄。通过一份标准化问卷评估了被认为会增加多房棘球绦虫暴露的行为以及这些行为在参与者生活中发生的时间顺序。病例患者比对照者更有可能一生都养狗（优势比6.00，P<0.05），把狗拴在房子附近（优势比8.50，P<0.05），并且居住在直接建在冻原上而非建在砾石或永久性地基上的房屋（优势比11.00，P<0.01）。病例患者并不更有可能养过雪橇犬、捕捉或剥狐狸皮，或从事其他离家的户外活动。这些发现表明，控制家犬种群中的寄生虫以及控制犬只数量本身，是在阿拉斯加西北部原住民人群中预防泡型包虫病的重要方面。
We studied 19 Eskimo patients with alveolar hydatid disease from the northwestern coast of Alaska for risk factors for infection with Echinococcus multilocularis. Each case-patient was matched by age and sex with 2 unrelated controls who had no clinical or serologic evidence of infection with E. multilocularis and who resided in three villages endemic for alveolar hydatid disease. Behaviors thought to increase exposure to E. multilocularis and the chronologic occurrence of these behaviors in the participant''s life were assessed by a standardized questionnaire. Case-patients were more likely than contols to have owned dogs for their entire lives (odds ratio 6.00, P < 0.05), tethered their dogs near the house (odds ratio 8.50, P < 0.05), and lived in houses built directly on the tundra rather than on gravel or a permanent foundation (odds ratio 11.00, P < 0.01). Case-patients were not more likely to have owned sled dogs, trapped or skinned foxes, or engaged in other outdoor activities away from home. These findings suggest that controlling the parasite in the domestic dog population, as well as controlling the dog population itself, are important aspects of preventing alveolar hydatid disease in the northwestern Native Alaskan population.