DIETARY INDUCTION OF INTESTINAL FRUCTOSE ABSORPTION IN WEANING RATS
DIETARY INDUCTION OF INTESTINAL FRUCTOSE ABSORPTION IN WEANING RATS
复制标题
DOI：
10.1203/00006450-199506000-00017
复制
发表时间：
1995-06-01
影响因子：
3.6
通讯作者：
FERRARIS, RP
中科院分区：
文献类型：
--
作者：
DAVID, ES;CINGARI, DS;FERRARIS, RP
发育诱导的大鼠肠道营养吸收变化的发生是众所周知的：刷状缘葡萄糖和果糖转运蛋白分别出现在产前和断奶后时期。然而，饮食诱导调节的开始尚不清楚。为了检验断奶期间和断奶后肠道葡萄糖和果糖运输受饮食调节的假设，我们给大鼠喂食含有高（65%）葡萄糖、高果糖、高蔗糖或不含碳水化合物的实验饮食。在 16 日龄大鼠中，与对照大鼠（母亲喂养并获得食物）相比，6 天的膳食果糖而非葡萄糖适度增加了小肠 (SI) 外翻套管中的果糖吸收 (p = 0.02)。在 21 日龄（存在蔗糖酶的年龄）大鼠中，与对照大鼠和饲喂高葡萄糖或无碳水化合物饮食的大鼠相比，膳食果糖和蔗糖均显着增强（p = 0.004）果糖吸收。在 35 日（断奶后）和 60 日龄的大鼠中，与饲喂无碳水化合物饮食的大鼠相比，膳食果糖和蔗糖（而非葡萄糖）刺激果糖吸收（p < 0.005）。在所有年龄组中，肠道葡萄糖吸收与饮食无关（p大于或等于0.12），实验大鼠的生长速度与对照大鼠相同。近端和中部的果糖或葡萄糖吸收量是远端 SI 的 2-3 倍。即使在断奶早期，饮食也可以诱导肠道果糖（而非葡萄糖）的吸收，而膳食果糖和蔗糖是最有效的诱导剂。因此，饮食调节机制可以在个体发生上发生改变，并且早期引入某些饮食可以诱导某些营养转运蛋白的出现。
The onset of developmentally induced changes in rat intestinal nutrient absorption is well known: brushborder glucose and fructose transporters appear during prenatal and postweaning periods, respectively. The onset of diet-induced regulation, however, is unknown. To test the hypothesis that intestinal glucose and fructose transport is regulated by diet during weaning and postweaning, we fed rats experimental diets containing high (65%) glucose, high fructose, high sucrose, or no carbohydrate. In 16-d-old rats, 6 d of dietary fructose but not glucose modestly increased fructose absorption in everted sleeves of small intestine (SI) over control (mother-fed with access to chow) rats (p = 0.02). In 21-d-old (age when sucrase is present) rats, dietary fructose and sucrose each dramatically enhanced (p = 0.004) fructose absorption over control rats and rats fed high glucose or carbohydrate-free diets. In 35- (postweaning) and 60-d-old rats, dietary fructose and sucrose, but not glucose, stimulated fructose absorption (p < 0.005) over rats fed a carbohydrate-free diet. In all age groups, intestinal glucose absorption was independent of diet (p greater than or equal to 0.12), and experimental rats grew at the same rate as control rats. Absorption of fructose or glucose was 2-3 times greater in the proximal and middle than in the distal SI. Intestinal fructose, but not glucose, absorption can be induced by diet even during early weaning, and dietary fructose followed by sucrose is the most potent inducer. Thus, mechanisms of diet regulation can change ontogenetically, and early introduction of certain diets can induce appearance of certain nutrient transporters.