Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors
Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors
复制标题
DOI：
10.1053/j.gastro.2012.03.001
复制
发表时间：
2012-06-01
期刊：
影响因子：
29.4
通讯作者：
Hirano, Ikuo
中科院分区：
文献类型：
--
作者：
Gonsalves, Nirmala;Yang, Guang-Yu;Hirano, Ikuo
背景与目的：成人嗜酸性粒细胞性食管炎（EoE）通常表现为吞咽困难和食物嵌塞。6食物消除饮食（SFED）对EoE儿童有效。我们评估了SFED后重新进食对EoE成人的组织学反应、症状和生活质量的影响。方法：在研究开始时，50名患有EoE的成年人接受了食管胃镜检查（EGD），活检和食物和空气过敏原的皮肤点刺试验。SFED治疗6周后，患者再次接受EGD和活检。组织学应答者，定义为
BACKGROUND & AIMS: Adults with eosinophilic esophagitis (EoE) typically present with dysphagia and food impaction. A 6-food elimination diet (SFED) is effective in children with EoE. We assessed the effects of the SFED followed by food reintroduction on the histologic response, symptoms, and quality of life in adults with EoE. METHODS: At the start of the study, 50 adults with EoE underwent esophagogastroduodenoscopies (EGDs), biopsies, and skin-prick tests for food and aeroallergens. After 6 weeks of SFED, patients underwent repeat EGD and biopsies. Histologic responders, defined by