PrLZ Expression Is Associated With the Progression of Prostate Cancer LNCaP Cells
PrLZ Expression Is Associated With the Progression of Prostate Cancer LNCaP Cells
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PrLZ 表达与前列腺癌 LNCaP 细胞的进展相关
DOI：
10.1002/mc.20481
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发表时间：
2009-05-01
影响因子：
4.6
通讯作者：
He, Dalin
中科院分区：
文献类型：
--
作者：
Li, Lei;Zhang, Dong;He, Dalin
PrLZ是一个新近发现的在前列腺组织中特异表达的新基因。PrLZ在前列腺胚胎组织和雄激素非依赖性前列腺癌细胞中特异性表达增高，提示其可能与胚胎发育和恶性进展有关。然而，PrLZ在前列腺癌进展过程中的功能和机制仍不清楚。本研究发现PrLZ的表达可增强前列腺癌动物模型的体外增殖和侵袭能力，并可增加前列腺癌原位动物模型的致瘤性，提示PrLZ的表达促进了前列腺癌的恶性进展。此外，PrLZ还可能上调雄激素受体（AR）的表达，增加AR下游靶基因PSA的表达，提示PrLZ介导的前列腺癌恶性进展与雄激素信号有关。© 2008 Wiley利斯公司
PrLZ is a novel recent isolated gene and specific expression in prostate tissues. PrLZ expression was specifically elevated in prostate embryonic tissues and androgen independent prostate cancer cells, suggesting it might be association with the embryonic development and malignancy progression. However, the function and mechanism of PrLZ during the progression of prostate cancer remain blurred. Our present studies showed PrLZ expression might enhance the proliferation and invasion capability in vitro and also increase the tumorigenicity in situ prostate cancer animal model, which is indicated PrLZ expression contributed to the malignancy progression of prostate cancer. In addition, PrLZ also might up regulate androgen receptor (AR) expression and increase the PSA expression, a putative downstream target gene of AR, which indicated PrLZ mediated the malignancy progression of prostate cancer was associated with androgen signals. © 2008 Wiley‐Liss, Inc.