Impact of HAART and injection drug use on life expectancy of two HIV-positive cohorts in British Columbia
Impact of HAART and injection drug use on life expectancy of two HIV-positive cohorts in British Columbia
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DOI：
10.1097/01.aids.0000206508.32030.92
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发表时间：
2006-02-14
期刊：
影响因子：
3.8
通讯作者：
Hogg, RS
中科院分区：
文献类型：
--
作者：
Lloyd-Smith, E;Brodkin, E;Hogg, RS
背景：高效抗逆转录病毒疗法的引入使艾滋病毒感染者的生存率得到了持续改善。然而，有证据表明，并不是所有的人群都同样受益于HAART，并且HIV感染的注射吸毒者的死亡率高于非吸毒者。目的：根据注射吸毒史和HAART治疗史，对HIV阳性个体的预期寿命进行细分。设计：不列颠哥伦比亚省HIV/ AIDS治疗计划中HIV阳性者的基于人群的研究。方法：在这项研究中的主要结果的措施是预期寿命在确切的年龄20和潜在年的寿命losed.Results：最高的预期寿命（38.9年）和最低的潜在年的寿命损失的个人采取高效抗逆转录病毒治疗，没有注射吸毒史。最低的预期寿命（19.1年）和最高的潜在寿命损失的年数在HIV阳性注射吸毒者谁不服用HAART.Conclusions：有很大的差距，在预期寿命的人与艾滋病毒感染者在不列颠哥伦比亚省。注射毒品群体的成员，特别是那些没有服用HAART的人，与没有吸毒史的人相比，死亡率升高。(C)2006年利平科特威廉姆斯&威尔金斯。
Background: The introduction of HAART has led to consistent improvements in survival among HIV-infected individuals. However, there is evidence that not all populations have benefited equally from HAART and that mortality rates are higher in HIV-infected injection drug users than in non-users.Objective: To model life expectancies for HIV-positive individuals subdivided according to history of injection drug use and treatment with HAART.Design: Population-based study of HIV-positive persons in British Columbia's HIV/ AIDS treatment program.Methods: The primary outcome measures in this study were life expectancy at exact age 20 and potential years of life lost.Results: The highest life expectancy (38.9 years) and lowest potential years of life lost were measured for individuals taking HAART and without a history of injection drug use. The lowest life expectancy (19.1 years) and highest potential years of life lost were measured in HIV-positive injection drug users who were not taking HAART.Conclusions: There are substantial disparities in life expectancy for persons living With HIV in British Columbia. Members of the injection drug community, particularly those who are not taking HAART, experience elevated mortality in comparison with those without a history of drug use. (C) 2006 Lippincott Williams & Wilkins.