Early-life exposure to EDCs: role in childhood obesity and neurodevelopment.
Early-life exposure to EDCs: role in childhood obesity and neurodevelopment.
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DOI：
10.1038/nrendo.2016.186
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Braun JM
中科院分区：
文献类型：
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作者：
Braun JM
内分泌干扰物（EDCs）可能会通过干扰妊娠期、婴儿期或儿童期对生长和发育至关重要的经尿道介导的过程来增加儿童疾病的风险。胎儿，婴儿和儿童可能对环境应激源（如EDCs）的敏感性增强，这是由于快速发育和更多地暴露于某些EDCs，这是由于他们发育适当的行为，解剖学和生理学。本文综述了流行病学研究，探讨早期生活暴露于双酚A（BPA），邻苯二甲酸酯，三氯生，和全氟烷基物质（PFAS）与儿童神经行为障碍和肥胖的关系。现有的流行病学证据表明，产前暴露于这些普遍存在的内分泌干扰物中的几种与不良神经行为（BPA和邻苯二甲酸酯）和过度肥胖或肥胖/超重（PFAS）风险增加有关。量化EDC混合物的影响，改善EDC暴露评估，减少混淆的偏倚，识别高度脆弱的时期，并阐明性二态EDC效应的存在和性质，将导致流行病学研究的更强的推论。最终，更好地估计电子数据采集器暴露对儿童健康的因果影响可以帮助识别易感亚群，并采取公共卫生干预措施来减少这些暴露。
Endocrine disrupting chemicals (EDCs) may increase the risk of childhood diseases by disrupting hormonally mediated processes critical for growth and development during gestation, infancy, or childhood. The fetus, infant, and child may have enhanced sensitivity to environmental stressors like EDCs due to rapid development and greater exposure to some EDCs that results from their developmentally appropriate behavior, anatomy, and physiology. This review summarizes epidemiological studies examining the relations of early-life exposure to bisphenol A (BPA), phthalates, triclosan, and perfluoroalkyl substance (PFAS) with childhood neurobehavioral disorders and obesity. The available epidemiological evidence suggests that prenatal exposure to several of these ubiquitous EDCs is associated with adverse neurobehavior (BPA and phthalates) and excess adiposity or increased risk of obesity/overweight (PFAS). Quantifying the effects of EDC mixtures, improving EDC exposure assessment, reducing bias from confounding, identifying periods of heightened vulnerability, and elucidating the presence and nature of sexually dimorphic EDC effects would result in stronger inferences from epidemiological studies. Ultimately, better estimates of the causal effects of EDC exposures on child health could help identify susceptible sub-populations and lead to public health interventions to reduce these exposures.