Chromones from the Tobacco Derived Fungus Aspergillus versicolor and Their Antiviral Activity
Chromones from the Tobacco Derived Fungus Aspergillus versicolor and Their Antiviral Activity
复制标题
DOI：
10.1007/s10600-023-04024-5
复制
发表时间：
2023-05
影响因子：
0.8
通讯作者：
S. Shen;W. Xiong;Shan-Shan Li-Shan;Xiao-Shan Liu;Yin-ke Li;Dong Miao;Xue-mei Li;Wei-Guang Wang;Gang Du;Daping Gong;Qiu-Fen Hu;Xiao Ma
中科院分区：
文献类型：
--
作者：
S. Shen;W. Xiong;Shan-Shan Li-Shan;Xiao-Shan Liu;Yin-ke Li;Dong Miao;Xue-mei Li;Wei-Guang Wang;Gang Du;Daping Gong;Qiu-Fen Hu;Xiao Ma
从烟草内生真菌杂色曲霉的发酵产物中分离得到两个新的色酮化合物8-(3-hydroxypropyl)-2-(3-hydroxy-1-oxopropyl)-6-methoxy-4H-chromen-4-one(1)，2-acetyl-8-(3-hydroxypropyl)-6-methoxy-4H-chromen-4-one(2)和4个已知的色酮化合物(3-6)。通过波谱方法，包括广泛的1D和2D核磁共振技术，确定了它们的结构。对化合物1和2进行了抗烟草花叶病毒(TMV)活性评价。结果表明，化合物1和2具有潜在的抗烟草花叶病毒活性，抑制率分别为35.3%和30.6%，接近阳性对照。
Two new chromones, 8-(3-hydroxypropyl)-2-(3-hydroxy-1-oxopropyl)-6-methoxy-4H-chromen-4-one (1), 2-acetyl-8-(3-hydroxypropyl)-6-methoxy-4H-chromen-4-one (2), along with four known ones (3–6) were isolated from the fermentation products of an endophytic fungusAspergillus versicolorderived from tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds1and2were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds1and2exhibited potential anti-TMV activities with inhibition rates of 35.3 and 30.6%, respectively, rates that are close to that of positive control.