Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation.
Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation.
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DOI：
10.4137/cmc.s8445
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Dobrev D
中科院分区：
文献类型：
--
作者：
Heijman J;Heusch G;Dobrev D
房颤仍然是临床上最常见的心律失常。屈诺达龙是一种用于维持房颤患者窦性心律的抗心律失常药物。屈诺达龙是一种胺碘酮衍生物，开发用于减少心血管外副作用的数量。在过去的十年中，Dronedarone进行了广泛的实验和临床测试。总体而言，这些研究强调了一系列复杂的多效性作用，这些作用可能有助于丹参酮的抗心律失常作用。在这篇综述中，我们总结了评价屈尼达酮的临床研究，并对屈尼达酮的电生理和非电生理多效性作用进行了概述。
Atrial fibrillation remains the most common arrhythmia in clinical practice. Dronedarone is an antiarrhythmic drug for the maintenance of sinus rhythm in patients with atrial fibrillation. Dronedarone is an amiodarone derivative developed to reduce the number of extracardiovascular side effects. Dronedarone has undergone extensive experimental and clinical testing during the last decade. On the aggregate, these studies have highlighted a complex set of pleiotropic actions that may contribute to dronedarone’s antiarrhythmic effects. In this review, we summarize the clinical studies that have evaluated dronedarone and provide an overview of dronedarone’s electrophysiological and nonelectrophysiological pleiotropic actions.