Subjective health and fibrinogen in a healthy Chinese cohort.
Subjective health and fibrinogen in a healthy Chinese cohort.
复制标题
健康中国人群的主观健康状况和纤维蛋白原。
DOI：
10.1348/1359107042304533
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发表时间：
2004
影响因子：
7.9
通讯作者：
E. Janus
中科院分区：
文献类型：
--
作者：
R. Fielding;T. Lam;S. Ho;E. Janus
目标
本研究探讨了健康人群样本中的标准心血管 (CVD) 危险因素，其中 CVD 患病率较低，并且假定较高的社会联系是连接主观健康 (SH) 和身体健康的潜在机制。
方法
一项以人群为基础的电话抽样横断面研究招募了 2280 名健康的中国成年人，随后他们接受了免费体检。采用 4 点单项测量方法，对过去 3 个月内报告良好 SH 和报告较差 SH 的受访者之间的血清总胆固醇、低密度脂蛋白 (LDL)、高密度脂蛋白 (HDL)、甘油三酯、纤维蛋白原、空腹血糖、负荷后 2 小时血糖、血压和肥胖情况进行比较。
结果
调整年龄、性别、教育程度、运动、婚姻和吸烟状况后，只有血清纤维蛋白原使两组之间存在显着差异。与报告良好或非常好的 SH 的受访者相比，报告 SH 非常差或差的受访者平均纤维蛋白原水平升高的可能性显着更大（调整优势比 1.37，95% CL 1.002-1.84，p < .05）。
结论
在这一 CVD 患病率低的人群中，SH 与纤维蛋白原之间存在微小但牢固的关联，而已知的既存疾病无法解释这一关联。
OBJECTIVES
This study explores standard cardiovascular (CVD) risk factors in a healthy population sample, with low CVD prevalence and presumed higher social connectedness as potential mechanisms linking subjective health (SH) and physical health.
METHOD
A population-based, telephone-sampled, cross-sectional study recruited a healthy subset of 2280 Chinese adults who subsequently underwent a free medical examination. Serum total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides, fibrinogen, fasting glucose, 2-hour post-load glucose, blood pressure and adiposity were compared between respondents reporting good SH and those reporting poor SH over the past 3 months, on a 4-point, single-item measure.
RESULTS
After adjustment for age, gender, education, exercise, marital and smoking status, only serum fibrinogen significantly differentiated the two groups. Respondents reporting Very poor or Poor SH had a significantly greater likelihood of raised mean fibrinogen levels compared with those reporting Good or Very good SH (Adjusted Odds Ratio 1.37, 95% CL 1.002-1.84, p < .05).
CONCLUSIONS
There is a small but robust association between SH and fibrinogen in this low CVD prevalent population unexplained by known pre-existing disease.