IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens
IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens
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IL-17RE 是 IL-17C 的功能性受体，介导针对肠道病原体感染的粘膜免疫
DOI：
10.1038/ni.2155
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发表时间：
2011-12-01
影响因子：
30.5
通讯作者：
Qian, Youcun
中科院分区：
文献类型：
--
作者：
Song, Xinyang;Zhu, Shu;Qian, Youcun
白细胞介素17受体E（IL-17 RE）是IL-17受体家族的孤儿受体。在这里，我们表明IL-17 RE是IL-17 C的特异性受体，在宿主粘膜防御感染中具有重要作用。IL-17 C通过IL-17 RE-IL-17 RA复合物激活下游信号传导，以诱导编码抗菌肽以及促炎分子的基因。IL-17 C在鼠柠檬酸杆菌感染过程中表达上调，并与IL-22协同作用，诱导结肠上皮细胞表达抗菌肽。在IL-17 RE缺陷小鼠中，IL-17 C介导的信号传导的丧失导致编码抗菌分子的基因表达降低、细菌负荷增加和感染期间的早期死亡率。总之，我们的数据确定IL-17 RE作为IL-17 C的受体，其调节对肠道病原体的早期先天免疫。
Interleukin 17 receptor E (IL-17RE) is an orphan receptor of the IL-17 receptor family. Here we show that IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C activated downstream signaling through IL-17RE–IL-17RA complex for the induction of genes encoding antibacterial peptides as well as proinflammatory molecules. IL-17C was upregulated in colon epithelial cells during infection withCitrobacter rodentiumand acted in synergy with IL-22 to induce the expression of antibacterial peptides in colon epithelial cells. Loss of IL-17C-mediated signaling in IL-17RE-deficient mice led to lower expression of genes encoding antibacterial molecules, greater bacterial burden and early mortality during infection. Together our data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.