Angiopoietin-1 and-2 expression in recurrent squamous cell carcinoma of the oral cavity
Angiopoietin-1 and-2 expression in recurrent squamous cell carcinoma of the oral cavity
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DOI：
10.1002/jso.20930
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发表时间：
2008-03-01
影响因子：
2.5
通讯作者：
Huang, Chao-Cheng
中科院分区：
文献类型：
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作者：
Chien, Chih-Yen;Su, Chih-Ying;Huang, Chao-Cheng
背景与目的：探讨血管生成素-1(Ang-1)和血管生成素-2(Ang-2)在复发性可手术口腔鳞癌(OCSCC)中的表达及其临床意义。方法：对1995-2005年间收治的40例局部或局部复发性口腔鳞癌患者手术切除的石蜡包埋组织标本进行Ang-1和Ang-2免疫组织化学分析。结果：复发性TNM分期：I期5例，II期4例，III期2例，IV期29例。3年无瘤生存率43.1%，随访1~70个月，平均18.4个月。Ang-1的高表达与阳性结节分期显著相关(P=0.041)。复发分期越晚(P=0.0036)、血管紧张素转换酶2高表达(P=0.045)的患者，其3年无瘤生存率越低。COX回归分析显示，复发(RT)分期是影响患者生存的独立预后因素(P=0.019，95%CI=1.473~82.017，相对危险度=10.992)。结论：复发的口腔鳞状细胞癌中Ang-1或Ang-2高表达具有侵袭性。然而，抢救结果取决于RT阶段。
Background and Objectives: Our objective was to evaluate the clinical significance of angiopoietin-1 (Ang-1) and Ang-2 expression in recurrent but operable squamous cell carcinoma of the oral cavity (OCSCC). Patients andMethods: Formalin-fixed, paraffin-embedded tissues from 40 patients who underwent surgical intervention for local or local-regional recurrent OCSCC between 1995 and 2005 were immunohistochemically analyzed for Ang-1 and Ang-2 expression.Results: The recurrent TNM staging classified 5 patients as stage I, 4 as stage II, 2 as stage III, and 29 as stage IV. The actuarial 3-year disease-free survival rate was 43.1% with a mean follow-up of 18.4 months (ranged 1-70 months). High expression of Ang-1 was significantly correlated with positive nodal stage (P=0.041). Patients with more advanced recurrent stage of the tumors (P=0.0036) and high expression of Ang-2 (P=0.045) showed lower actuarial 3-year disease-free survival. However, Cox's regression analysis revealed that only recurrent tumor (rT) stage was an independent prognostic factor for survival (P=0.019, 95% CI = 1.473-82.017, relative risk = 10.992).Conclusions: Recurrent OCSCC with high Ang-1 or Ang-2 expression in the tumor bed exhibits aggressive tumor behavior. However, the salvage outcome depends on the rT stage.