Wheat bran feruloyl oligosaccharides modulate the phase II detoxifying/antioxidant enzymes via Nrf2 signaling
Wheat bran feruloyl oligosaccharides modulate the phase II detoxifying/antioxidant enzymes via Nrf2 signaling
复制标题
麦麸阿魏酰低聚糖通过 Nrf2 信号调节 II 相解毒/抗氧化酶
DOI：
10.1016/j.ijbiomac.2014.12.011
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发表时间：
2015-03-01
影响因子：
8.2
通讯作者：
Sun, Baoguo
中科院分区：
文献类型：
--
作者：
Zhang, Huijuan;Wang, Jing;Sun, Baoguo
The antioxidant activities of wheat bran feruloyl oligosaccharides (FOs) were determined in rats by determining the activities and mRNA expression levels of phase II detoxifying/antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and heme oxygenase-1 (HO-1) in rat organs. FOs was given by gavage at doses of 0.25, 0.5, and 0.75 mmol/kg body weight every day for 15 days. Compared with the control group,,the activities of SOD, CAT, and GSH-Px in FOs treatment groups significantly (P < 0.05) increased in heart, liver, and kidney. All the FOs treatment also significantly (P < 0.05) increased the glutathione (GSH) contents in heart (28-58%), liver (32-71%), and kidney (31-73%) compared with the control. FOs up regulated the mRNA expression levels of SOD, CAT, and HO-1 in organs. Moreover, the immunoblot analysis revealed increased nuclear factor-E2-related factor (Nrf2) protein expression levels in organs and there were positive correlations between the mRNA expression of phase II detoxifying/antioxidant enzymes and the expressions of Nrf2 protein, which demonstrated FOs treatment could modulate the detoxifying/antioxidant enzymes via Nrf2 signaling. (C) 2014 Published by Elsevier B.V.
