Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China
Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China
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DOI：
10.1289/ehp4913
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发表时间：
2019-09-01
影响因子：
10.4
通讯作者：
Lan, Qing
中科院分区：
文献类型：
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作者：
Vermeulen, Roel;Downward, George S.;Lan, Qing
背景技术背景：中国宣威和抚远从不吸烟的妇女肺癌发病率是世界上最高的，这归因于家庭取暖和做饭使用的是烟煤。然而，导致肺癌风险的煤的关键成分还没有被确定。结论：我们的目的是调查终身暴露于煤烟成分之间的关系，（和其他燃料类型）和肺癌。使用基于人群的肺癌病例对照研究，包括1，015例从不吸烟的女性病例和485例对照，我们研究了接触43种家庭空气污染物与肺癌之间的关系。污染物预测来自一项全面的暴露评估研究，其中包括甲基化多环芳烃（PAH），这从未在任何癌症的流行病学研究中直接评估。为了解决暴露变量的高共线性，应用了分层聚类和惩罚回归。结果：与肺癌的最强关联是25种多环芳烃的聚类[比值比（OR）：2.21; 95%置信区间（CI）：1.67，2.87/1标准差（SD）变化]，其中5-甲基喹啉（5-MC），一种致突变和致癌PAH，具有最高的个体观察OR（5.42; 95% CI：0.94，27.5）。还观察到与二氧化氮（NO2）呈正相关（OR：2.06; 95% CI：1.19，3.49）。相比之下，苯并（a）芘（BaP）和空气动力学直径的细颗粒物
BACKGROUND: Lung cancer rates among never-smoking women in Xuanwei and Fuyuan in China are among the highest in the world and have been attributed to the domestic use of smoky (bituminous) coal for heating and cooking. However, the key components of coal that drive lung cancer risk have not been identified.OBJECTIVES: We aimed to investigate the relationship between lifelong exposure to the constituents of smoky coal (and other fuel types) and lung cancer.METHODS: Using a population-based case-control study of lung cancer among 1,015 never-smoking female cases and 485 controls, we examined the association between exposure to 43 household air pollutants and lung cancer. Pollutant predictions were derived from a comprehensive exposure assessment study, which included methylated polycyclic aromatic hydrocarbons (PAHs), which have never been directly evaluated in an epidemiological study of any cancer. Hierarchical clustering and penalized regression were applied in order to address high colinearity in exposure variables.RESULTS: The strongest association with lung cancer was for a cluster of 25 PAHs [odds ratio (OR): 2.21; 95% confidence interval (CI): 1.67, 2.87 per 1 standard deviation (SD) change], within which 5-methylchrysene (5-MC), a mutagenic and carcinogenic PAH, had the highest individual observed OR (5.42; 95% CI: 0.94, 27.5). A positive association with nitrogen dioxide (NO2) was also observed (OR: 2.06; 95% CI: 1.19, 3.49). By contrast, neither benzo(a)pyrene (BaP) nor fine particulate matter with aerodynamic diameter