AHR in the skin: From the mediator of chloracne to a therapeutic panacea?
AHR in the skin: From the mediator of chloracne to a therapeutic panacea?
复制标题
DOI：
10.1016/j.cotox.2017.02.002
复制
发表时间：
2017-02-01
影响因子：
4.6
通讯作者：
Esser, Charlotte
中科院分区：
文献类型：
--
作者：
Merches, Katja;Haarmann-Stemmann, Thomas;Esser, Charlotte
转录因子AHR在所有皮肤细胞中高度表达，越来越多的证据表明其参与屏障器官的免疫。AHR被环境中发现的许多分子激活，包括人造和天然化合物，例如，从食用植物。还鉴定了AHR的内源性激活剂。我们在这里回顾了激活AHR对皮肤完整性和皮肤健康的有利和不利功能。我们确定了开放性问题，并假设并发炎症事件如何影响皮肤中生理AHR信号传导的结果。AHR是一个非常有趣的治疗靶点，但不同的配体可能导致完全不同的免疫效应。潜在的原因，如配体诱导的构象变化的可能差异，往往是不清楚或推测。这仍然是治疗用途的挑战。此外，表观遗传变化等长期影响需要更多地关注。
The transcription factor AHR is highly expressed in all skin cells and an increasing body of evidence shows its involvement in immunity of barrier organds. The AHR is activated by many molecules found in the environment, both man-made and natural compounds, e.g., from dietary plants. Also endogenous activators of AHR were identified. We here review beneficial and adverse functions of activated AHR for skin integrity and skin health. We identify open questions, and hypothesize how concurrent inflammatory events can influence the outcome of physiological AHR signaling in the skin. AHR is a highly interesting therapeutic target, but different ligands can result in completely different immune effects. The underlying reasons, such as possible differences in ligand-induced conformational changes, are often unclear or speculative. This remains a challenge for therapeutic use. Also, long-term effects such as epigenetic changes need to come more into focus.