INTEREST IN GENETIC TESTING FOR COLON CANCER SUSCEPTIBILITY - COGNITIVE AND EMOTIONAL CORRELATES
INTEREST IN GENETIC TESTING FOR COLON CANCER SUSCEPTIBILITY - COGNITIVE AND EMOTIONAL CORRELATES
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DOI：
10.1006/pmed.1993.1023
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发表时间：
1993-03-01
影响因子：
5.1
通讯作者：
LERMAN, C
中科院分区：
文献类型：
--
作者：
CROYLE, RT;LERMAN, C
背景人类遗传学的最新进展导致了癌症易感性标记的鉴定。然而，公众对癌症相关标志物的临床基因检测的兴趣知之甚少。1990年夏天，对犹他州的401名成年居民进行了随机数字拨号电话调查。受访者被随机分配到三个问题框架中的一个，并询问他们对结肠癌易感性潜在基因检测的兴趣。他们还被要求评估他们患结肠癌的风险，他们担心感染任何类型癌症的频率，以及他们在过去一年中感到担忧和紧张的频率（特质焦虑）。83%的受访者表示对基因检测感兴趣。兴趣水平与结肠癌的感知风险最强相关（r= 0.21，P < 0.001）。使用不同的问题框架的反应并没有受到影响。这些结果表明，公众对结肠癌易感性基因检测的兴趣很高。数据还表明，焦虑并不会削弱兴趣，但未来的研究必须确定这种关系是否仅限于假设的判断，如本文所研究的。
Background. Recent advances in human genetics have led to the identification of markers for cancer susceptibility. Nevertheless, little is known about the public"s interest in clinical genetic testing for cancer-related markers.Methods. A random-digit-dial telephone survey of 401 adult residents of Utah was conducted during the summer of 1990. Respondents were randomized to one of three question frames and asked about their interest in a potential genetic test for colon cancer susceptibility. They were also asked to rate their risk for colon cancer, how often they worried about contracting any type of cancer, and how often they felt worried and nervous during the past year (trait anxiety).Results. Eighty-three percent of respondents expressed interest in genetic testing. Level of interest was most strongly correlated with perceived risk for colon cancer (r= 0.21,P< 0.001). Responses were not affected by the use of different question frames.Conclusions. These results show a high level of public interest in genetic testing for colon cancer susceptibility. The data also suggest that anxiety does not undermine interest, but future research must determine whether this relationship is limited to hypothetical judgments such as those studied here.