Relationship of hepatic steatosis and alanine aminotransferase with coronary calcification
Relationship of hepatic steatosis and alanine aminotransferase with coronary calcification
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DOI：
10.1515/cclm.2010.349
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发表时间：
2010-12-01
影响因子：
6.8
通讯作者：
Lee, Hye-Ree
中科院分区：
文献类型：
--
作者：
Jung, Dong-Hyuk;Lee, Yong-Jae;Lee, Hye-Ree
背景：已经观察到肝脂肪变性与心血管疾病（CVD）风险增加有关。丙氨酸氨基转移酶（ALT）是肝脂肪变性严重程度的指标，也与CVD相关。本研究的重点是肝脂肪变性和ALT与冠状动脉calcium.Methods之间的关系：我们进行了一项横断面研究，以检查1218例（772名男性，446名女性;年龄30-75岁）肝脂肪变性和血清ALT与冠状动脉calcium. Methods之间的关联。我们评估了肝脂肪变性和ALT作为分类变量，并构建了四个组（参考组;仅肝脂肪变性;仅ALT >30 U/L;肝脂肪变性和ALT >30 U/L），这些组不重叠。结果：校正混杂变量后，四组患者冠状动脉钙化的校正OR（95% CI）分别为1.00（参考值）、1.24（0.68-2.26）、1.82（0.78-4.23）和2.12（1.08-4.20）。此外，血清ALT活性增加10 U/L与冠状动脉粥样硬化的风险增加相关。结论：总之，肝脂肪变性和ALT增加的患者与冠状动脉钙化相关，作为冠状动脉粥样硬化的标志物，由MDCT确定。这一发现表明，应考虑对同时存在肝脂肪变性和ALT升高的受试者进行冠状动脉粥样硬化的进一步评价。临床化学实验室医学2010; 48：1829-34。
Background: It has been observed that hepatic steatosis is related to an increased risk of cardiovascular disease (CVD). Alanine aminotransferase (ALT), an indicator of the severity of hepatic steatosis is also associated with CVD. This study focused on the relationship between hepatic steatosis and ALT with coronary calcification.Methods: We performed a cross-sectional study to examine the association between hepatic steatosis and serum ALT with coronary calcification in 1218 subjects (772 men, 446 women; ages 30-75 years). We evaluated hepatic steatosis and ALT as categorical variables, and constructed four groups (reference group; only with hepatic steatosis; only with ALT >30 U/L; with both hepatic steatosis and ALT >30 U/L), which did not overlap. Multi-detected row computed tomography (MDCT) was used to measure coronary calcium score.Results: The adjusted ORs (95% CIs) for coronary calcification in the four groups were 1.00 (reference), 1.24 (0.68-2.26), 1.82 (0.78-4.23), and 2.12 (1.08-4.20) after adjusting for confounding variables. In addition, an increase in serum ALT activity of 10 U/L was associated with an increased risk of coronary atherosclerosis.Conclusions: In summary, patients with both hepatic steatosis and increases in ALT are associated with coronary calcification as a marker of coronary atherosclerosis determined by MDCT. This finding suggested that subjects with both hepatic steatosis and increased ALT should be considered for further evaluation of coronary atherosclerosis. Clin Chem Lab Med 2010; 48:1829-34.