Canine dilated cardiomyopathy: a retrospective study of prognostic findings in 367 clinical cases
Canine dilated cardiomyopathy: a retrospective study of prognostic findings in 367 clinical cases
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DOI：
10.1111/j.1748-5827.2010.00966.x
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发表时间：
2010-08-01
影响因子：
1.6
通讯作者：
King, J. N.
中科院分区：
文献类型：
--
作者：
Martin, M. W. S.;Johnson, M. J. Stafford;King, J. N.
方法：对367只DCM犬进行回顾性观察研究。使用Kaplan-Meier方法加上单因素和多因素Cox比例风险模型分析了死亡或因心脏原因安乐死前的生存时间。双尾P值小于0中心点0.05被认为具有统计学意义。结果：在多变量模型中，左心室直径（LVDs）指数（P=0中心点0067）、影像学上肺水肿的存在（P=0中心点043）、心室过早复核（VPCs）的存在（P=0中心点0012）、血浆肌酐升高（P=0中心点0002）、血浆蛋白降低（P=0中心点029）和大丹犬品种（P=0中心点0003）与生存率呈负相关。大多数狗接受血管紧张素转换酶抑制剂（93%）或呋塞米（86%）治疗，许多狗接受地高辛（50%）和/或匹莫苯丹（30%）治疗。13只狗被随访。本研究未得出药物使用与生存之间关系的结论。临床意义：lvds指数是评估本组DCM犬预后的单一最佳变量。其他与生存负相关的变量是x线片上肺水肿的存在、VPCs的存在、较高的血浆肌酐、较低的血浆蛋白和大丹犬品种。
Methods: A retrospective observational study of 367 dogs with DCM. Survival times until death or euthanasia for cardiac reasons were analysed using the Kaplan-Meier method plus univariate and multivariate Cox proportional hazards models. Two-tailed P values less than 0 center dot 05 were considered statistically significant.Results: In the multivariate model, left ventricular diameter (LVDs)-index (P=0 center dot 0067), presence of pulmonary oedema on radio-graphy (P=0 center dot 043), presence of ventricular premature complexes (VPCs) (P=0 center dot 0012), higher plasma creatinine (P=0 center dot 0002), lower plasma protein (P=0 center dot 029) and great Dane breed (P=0 center dot 0003) were negatively associated with survival. Most dogs were treated with angiotensin-converting enzyme inhibitors (93%) or furosemide (86%), and many received digoxin (50%) and/or pimobendan (30%). Thirteen dogs were lost to follow-up. No conclusions could be made in this study on the association between use of drugs and survival.Clinical Significance: The LVDs-index was the single best variable for assessing the prognosis in this group of dogs with DCM. Other variables that were negatively associated with survival were presence of pulmonary oedema on radiography, presence of VPCs, higher plasma creatinine, lower plasma protein and great Dane breed.