Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR.
Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR.
复制标题
合成 9E 和 9Z 锁定视黄酸类似物作为 RAR 和 RXR 的配体。
DOI：
10.1248/cpb.42.2659
复制
发表时间：
1994
影响因子：
1.7
通讯作者：
M. Ito
中科院分区：
文献类型：
--
作者：
Y. Katsuta;Y. Aoyama;H. Osone;A. Wada;S. Uchiyama;T. Kitamoto;S. Masushige;S. Kato;M. Ito
以二噻烷6和β-环柠檬醛13为原料合成了新的维甲酸类似物9 E-locked-RA 3和9 Z-locked-RA 4。这两种类似物表现为视黄酸受体（RAR）和类维生素A X受体（RXR）的混合物的激动配体。
New retinoic acid (RA) analogs 9E-locked-RA 3 and 9Z-locked-RA 4 were synthesized from dithiane 6 and beta-cyclocitral 13, respectively. Both analogs behaved as agonistic ligands for a mixture of retinoic acid receptor (RAR) and retinoid X receptor (RXR).