Donepezil for Treatment of Dementia With Lewy Bodies: A Case Series of Nine Patients
Donepezil for Treatment of Dementia With Lewy Bodies: A Case Series of Nine Patients
复制标题
多奈哌齐治疗路易体痴呆：九名患者的病例系列
DOI：
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发表时间：
1998
影响因子：
7
通讯作者：
K. Rockwood
中科院分区：
文献类型：
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作者：
Catherine Shea;C. MacKnight;K. Rockwood
路易体痴呆（DLB）是常见的。症状治疗可能很困难。我们回顾了9例连续的DLB患者（平均年龄77.5 [范围67至84]岁; 7名男性和2名女性;平均病程3.7 [范围1.5至8.0]年），他们都接受了多奈哌齐治疗。每个人最初每天接受2.5至5 mg的多奈哌齐，并稳定在每天5 mg。5例患者将多奈哌齐增加至10 mg/天。平均观察期为12周（范围8 - 24周）。目标症状包括认知、幻觉、帕金森综合征和功能性能力。通过认知测试和家庭报告，9名患者中有7名患者的认知有所改善，9名患者中有1名患者的认知保持不变，9名患者中有1名患者的认知有所波动（平均简易精神状态检查变化4.4 ± 6.3分）。9名患者中有6名患者的功能得到改善或维持，9名患者中有2名患者的功能有所波动。一名患者的幻觉最初恶化，然后波动，但9例病例中有8例报告了频率，持续时间和内容的改善。在9名患者中的3名中，多奈哌齐治疗导致帕金森综合征恶化，在每种情况下都对左旋多巴/卡比多巴有反应。用多奈哌齐治疗DLB患者12周最常见的是改善幻觉，有时改善认知和整体功能。多奈哌齐治疗有时与更严重的帕金森症有关。
Dementia with Lewy bodies (DLB) is common. Symptomatic treatment can be difficult. We reviewed nine consecutive patients with DLB (mean age 77.5 [range 67 to 84] years; seven men and two women; mean duration of disease 3.7 [range 1.5 to 8.0] years) who had been treated with donepezil. Each initially received 2.5 to 5 mg per day of donepezil, and was stabilized on 5 mg per day. Donepezil was increased to 10 mg per day in five patients. The mean observation period was 12 (range 8 to 24) weeks. Target symptoms included cognition, hallucinations, parkinsonism, and functional abilities. By both cognitive testing and family reports, cognition improved in seven of nine patients, remained the same in one of nine, and fluctuated in one of nine (mean Mini-Mental State Examination change 4.4 ± 6.3 points). Function was improved or maintained in six of nine patients and fluctuated in two of nine. Hallucinations initially worsened, then fluctuated in one patient, but improvement in frequency, duration, and content was reported in eight of nine cases. In three of nine patients, treatment with donepezil resulted in worsening of parkinsonism, which in each case responded to levodopa/carbidopa. Treatment of DLB patients with donepezil for 12 weeks most commonly improved hallucinations, and sometimes improved cognition and overall function. Treatment with donepezil was sometimes associated with worse parkinsonism.
DOI：
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发表时间：
1991
期刊：
The Psychiatric clinics of North America
影响因子：
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作者：
Kluger,A;Ferris,SH
通讯作者：
Ferris,SH
影响因子：
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作者：
B. Reisberg;S. Ferris
通讯作者：
B. Reisberg;S. Ferris