A dual-function all-inorganic intercluster salt comprising the polycation ε-[Al13O4(OH)24(H2O)12]7+ and polyanion α-[PMo10V2O40]5- for detoxifying sulfur mustard and soman.
A dual-function all-inorganic intercluster salt comprising the polycation ε-[Al13O4(OH)24(H2O)12]7+ and polyanion α-[PMo10V2O40]5- for detoxifying sulfur mustard and soman.
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DOI：
10.1039/d0dt01307b
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发表时间：
2020-06
影响因子：
4
通讯作者：
Jialin Yu;Q. Gao;Lijuan Zhang;Yunshan Zhou;Yuxu Zhong;Jianbo Yin;Yuanyuan Zhou;Fang-Ling Tao
中科院分区：
文献类型：
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作者：
Jialin Yu;Q. Gao;Lijuan Zhang;Yunshan Zhou;Yuxu Zhong;Jianbo Yin;Yuanyuan Zhou;Fang-Ling Tao
选择与磷酸三酯酶活性中心ZnII-OH-ZnII相似的ε-[Al_（13）O_4（OH）_（24）（H_2 O）_（12）]_（7+）与簇合物α-PMo_（10）V_（2 O）_（40）5-相互作用，形成一个新的三维簇合物，该簇合物属于单斜晶系，空间群为P21/m，Z = 2。实验结果表明，在室温条件下，50 mg该化合物对4 μL硫芥（HD）和4 μL梭曼（GD）的去污率分别为96.4%（120 min）和99.5%（40 min）。去污过程遵循一级反应动力学，HD的速率常数和半衰期分别为0.01234 min-1和56.15 min，GD的速率常数和半衰期分别为0.1198 min-1和5.78 min。结果表明，α-PMo_（10）V_2 O_（40）_5-基团催化氧化HD生成无毒的亚砜，而ε-[Al_（13）O_（4（OH）_（24）（H_2O）_（12）]_7+基团催化水解HD和GD生成无毒的水解产物。此外，该化合物对HD在豚鼠皮肤上的去污和GD在昆明小鼠皮肤上的去污表现出显著的效果，表明该化合物在人类皮肤保护和治疗中具有很高的潜力。
ε-[Al13O4(OH)24(H2O)12]7+, which shares similarity with the phosphotriesterase active site ZnII-OH-ZnII, was specially chosen to interact with the cluster α-PMo10V2O405- to form a new three-dimensional intercluster, which crystallized in the monoclinic space group P21/m with Z = 2, for the decontamination of chemical warfare agents. The experimental results showed that 50 mg of the compound decontaminated 96.4% (within 120 min) and 99.5% (within 40 min) of sulfur mustard (HD) (4 μL) and soman (GD) (4 μL), respectively, in ambient conditions. The decontamination processes followed first-order reaction kinetics with a rate constant and half-life of 0.01234 min-1 and 56.15 min for HD and 0.1198 min-1 and 5.78 min for GD, respectively. It was concluded that the α-PMo10V2O405- moiety was responsible for the catalytic oxidation of HD into non-toxic sulfoxide, while the ε-[Al13O4(OH)24(H2O)12]7+ moiety was responsible for the catalytic hydrolysis of HD and GD into nontoxic hydrolysates. Besides, the compound showed notable efficacy for the decontamination of HD on guinea pig skin and of GD on Kunming mouse skin, indicating high potential for use in human skin protection and treatment.