Research Techniques Made Simple: Animal Models of Wound Healing
Research Techniques Made Simple: Animal Models of Wound Healing
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DOI：
10.1016/j.jid.2018.08.005
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发表时间：
2018-10-01
影响因子：
6.5
通讯作者：
Falanga, Vincent
中科院分区：
文献类型：
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作者：
Grada, Ayman;Mervis, Joshua;Falanga, Vincent
已经开发了动物模型来研究伤口修复的复杂细胞和生化过程，并评估潜在治疗剂的功效和安全性。有几个因素会影响伤口愈合。这些因素包括衰老、感染、药物、营养、肥胖、糖尿病、静脉功能不全和外周动脉疾病。缺乏能够正确再现人类伤口的最佳临床前模型仍然是一个重大的转化挑战。动物模型应力求重现性、定量解释、临床相关性和成功转化为临床应用。在这篇简要的综述中，我们讨论了伤口实验中使用的动物模型，包括小鼠，大鼠，兔，猪和斑马鱼，特别强调受损的伤口愈合模型。
Animal models have been developed to study the complex cellular and biochemical processes of wound repair and to evaluate the efficacy and safety of potential therapeutic agents. Several factors can influence wound healing. These include aging, infection, medications, nutrition, obesity, diabetes, venous insufficiency, and peripheral arterial disease. Lack of optimal preclinical models that are capable of properly recapitulating human wounds remains a significant translational challenge. Animal models should strive for reproducibility, quantitative interpretation, clinical relevance, and successful translation into clinical use. In this concise review, we discuss animal models used in wound experiments including mouse, rat, rabbit, pig, and zebrafish, with a special emphasis on impaired wound healing models.