ABNORMALITIES OF BIOGENIC-AMINE METABOLISM
ABNORMALITIES OF BIOGENIC-AMINE METABOLISM
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DOI：
10.1007/bf00711900
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发表时间：
1993-01-01
影响因子：
4.2
通讯作者：
HYLAND, K
中科院分区：
文献类型：
--
作者：
HYLAND, K
术语生物胺是一个总括的术语，包括所有起源于生物过程的胺。本综述将仅限于影响5-羟色胺和儿茶酚胺代谢的生物胺异常。概述了这些神经递质的合成和分解代谢，并对主要影响其代谢的先天错误的神经学细节、生化特征和治疗进行了总结。还有一种想法提出，生物胺代谢异常比目前认为的要常见得多，对这些问题的研究可能适用于任何表现出未知原因的神经问题的新生儿或婴儿。
The term biogenic amine is an umbrella term that encompasses all amines with an origin in biological processes. This review will be restricted to the biogenic amine abnormalities that affect the metabolism of serotonin and the catecholamines. The synthesis and catabolism of these neurotransmitters are outlined, and a summary is given of the neurological details, biochemical features, and treatment of the inborn errors that primarily affect their metabolism. An idea is also developed that proposes that abnormalities of biogenic amine metabolism are far more common than is currently considered, and that the search for these problems may be appropriate in any neonate or infant who presents with neurological problems of unknown origin.