A MODEL FOR SIDEWALL ADHESIONS IN THE RABBIT REDUCTION BY AN ABSORBABLE BARRIER
A MODEL FOR SIDEWALL ADHESIONS IN THE RABBIT REDUCTION BY AN ABSORBABLE BARRIER
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DOI：
10.1002/micr.1920080406
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发表时间：
1987-01-01
期刊：
影响因子：
2.1
通讯作者：
DECHERNEY A H
中科院分区：
文献类型：
--
作者：
DIAMOND M P;LINSKY C B;DECHERNEY A H
尽管使用了手术辅助手段，但不孕症手术后仍经常发生盆腔粘连。最近，一种可吸收的生物相容性材料TC 7被设计用作屏障，以减少粘连形成。仅在6个受试模型中的一个模型中能够产生可再现的严重侧壁粘连。该模型由以下步骤组成：切除全厚度的2 × 10 - 2 mm的组织。2 cm肌腹膜组织肿块，刮除相邻2 cm长的子宫角，填塞所有出血，并缝合（6-0 Vicryl）正常输卵管和侧壁，以便直接缝合创伤组织。在13只家兔中进行了双侧侧壁和角损伤后的研究，每只家兔作为其自身的对照。随机选择对照侧和TC 7侧。术后2周检查粘连形成情况。当时未发现残留材料。粘连评分是侧壁粘连的程度（0-4）、类型（0-4）和韧性（0-3）的复合总和，并且与对照侧相比，TC 7侧的粘连评分显著降低（平均6.8 ± 0.5）。0.4相对于9.0 .+-。0.3，中位数6 vs 9，符号检验P = 0.0032）。未观察到使用防粘连膜的并发症。可以得出结论，使用TC 7（一种可吸收生物相容性屏障）能够显著减少家兔侧壁上的术后粘连形成。
Despite use of surgical adjuvants, pelvic adhesions frequently develop following infertility surgery. Recently a resorbable biocompatible material, TC 7, has been designed to be used as a barrier to reduce adhesion formation. Reproducibly severe sidewall adhesions were only able to be created in one of six models tested. The model consisted of the following steps: excision of a full thickness 2 .times. 2-cm musculoperitoneal tissue mass, scraping of an adjacent 2-cm length of uterine horn, tamponading of all bleeding, and suturing (6-0 Vicryl) of normal tube and sidewall so as to directly approximate the traumatized tissues. Studies were conducted in 13 rabbits after creation of the bilateral sidewall and horn lesions, each serving as its own control. Choice of control and TC7 sides was determined randomly. Adhesion formation was examined 2 weeks postoperatively. No residual material was noted at that time. Adhesion scores were the composite total of extent (0-4), type (0-4), and tenacity (0-3) of sidewall adhesions, and were significantly reduced on the TC 7 side as compared with the control side (mean 6.8 .+-. 0.4 vs 9.0 .+-. 0.3, median 6 vs 9, sign test P = 0.0032). No complications of use of the barrier were noted. It is concluded that use of TC 7, a resorbable biocompatible barrier, was able to significantly reduce postoperative adhesion formation on the rabbit sidewall.