Muscle impairments in patients with knee osteoarthritis.
Muscle impairments in patients with knee osteoarthritis.
复制标题
膝骨关节炎患者的肌肉损伤。
DOI：
10.1177/1941738112445726
复制
发表时间：
2012-07
期刊：
影响因子：
3.3
通讯作者：
Snyder-Mackler L
中科院分区：
文献类型：
--
作者：
Alnahdi AH;Zeni JA;Snyder-Mackler L
与膝关节骨关节炎（OA）相关的肌肉损伤是功能限制的主要根本原因。了解肌肉损伤的程度，其与身体功能和疾病进展的关系，以及针对肌肉损伤的运动疗法背后的证据至关重要。使用MEDLINE和CINHAL数据库对截至2011年9月的相关文章进行了电子检索。除电子检索外，还手动检索检索了检索到的文章以查找相关研究。与年龄匹配的对照组相比，膝关节骨性关节炎受试者的股四头肌、腘绳肌和臀部肌肉明显受损。肌肉力量，特别是股四头肌，是基于表现和自我报告的身体功能的主要决定因素。目前尚不清楚更强大的股四头肌是否可以预防膝关节OA的发生和进展。运动疗法，包括整体和有针对性的阻力训练，可有效减轻膝关节OA受试者的疼痛并改善其功能。患有膝关节OA的受试者具有显著的肌肉损伤。这些肌肉损伤会影响身体功能，应该在治疗中有针对性。需要进一步的研究来探索股四头肌力量与膝关节OA发生和进展之间的关系，并确定增加该患者人群结局的最佳运动处方。
Muscle impairments associated with knee osteoarthritis (OA) are the primary underlying cause of functional limitations. Understanding the extent of muscle impairments, its relationship with physical function and disease progression, and the evidence behind exercise therapy that targets muscle impairments is crucial. An electronic search for relevant articles using MEDLINE and CINHAL databases up to September 2011 was performed. In addition to the electronic search, retrieved articles were searched manually for relevant studies. Quadriceps, hamstrings, and hip muscles are significantly impaired in subjects with knee OA compared with age-matched controls. Muscle strength, especially quadriceps, is a major determinant of both performance-based and self-reported physical function. Whether stronger quadriceps is protective against knee OA onset and progression is not clear. Exercise therapy, including global and targeted resistance training, is effective in reducing pain and improving function in subjects with knee OA. Subjects with knee OA have significant muscle impairments. These muscle impairments affect physical function and should be targeted in therapy. Further research is needed to explore the relationship between quadriceps strength and knee OA initiation and progression and to determine the optimal exercise prescription that augments outcomes in this patient population.