One-pot three-component synthesis of 3-Amino-5,8-dioxo-5,8-dihydro-1H-pyrazolo[1,2-a]pyridazines
One-pot three-component synthesis of 3-Amino-5,8-dioxo-5,8-dihydro-1H-pyrazolo[1,2-a]pyridazines
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DOI：
10.1055/s-2007-990775
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发表时间：
2007-10-01
影响因子：
2.6
通讯作者：
Bijanzadeh, Hamid Reza
中科院分区：
文献类型：
--
作者：
Adib, Mehdi;Koloogani, Somayeh Aali;Bijanzadeh, Hamid Reza
异氰酸酯与二烷基乙酰二甲酸酯反应生成的1：1两性离子中间体被3，6-二羟基吡嗪捕获，以较高的产率合成了3-氨基-5，8-二氧代-5，8-二氢-1H-吡唑并[1，2-α]哒嗪。
The reactive 1: 1 zwitterionic intermediate formed by the addition of isocyanides to dialkyl acetylenedicarboxylates was trapped by 3,6-dihydroxypyridazine to produce 3-amino-5,8-dioxo-5,8-dihydro- 1 H-pyrazolo[ 1,2-alpha]pyridazines in good yields.