Two chronic motor training paradigms differentially influence acute instrumental learning in spinally transected rats
Two chronic motor training paradigms differentially influence acute instrumental learning in spinally transected rats
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DOI：
10.1016/j.bbr.2007.02.029
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发表时间：
2007-06-04
影响因子：
2.7
通讯作者：
Edgerton, V. Reggie
中科院分区：
文献类型：
--
作者：
Bigbee, Allison J.;Crown, Eric D.;Edgerton, V. Reggie
在新生（出生后第 5 天；P5）脊髓横断（即脊髓）大鼠中检查了两种慢性运动训练模式对腰脊髓执行急性乐器学习任务的能力的影响。与 P30 相似，大鼠开始单足后肢站立训练（Stand-Tr；20-25 分钟/天，5 天/周）或双足后肢迈步训练（Step-Tr；20 分钟/天；5 天/周），持续 7 周。未经训练的脊髓大鼠（Non-Tr）作为对照。 7周后，所有小组都接受了屈肌偏向的工具学习范式的测试。我们假设（1）Step-Tr 大鼠相对于非 Tr 受试者表现出更强的学习屈肌偏向任务的能力，因为运动涉及腓骨前肌（TA）的重复训练，腓骨前肌（TA）是踝屈肌，其激活对于成功的乐器学习很重要；（2）Stand-Tr 大鼠将表现出急性运动学习缺陷，因为单足训练激活同侧踝关节 伸肌，但不是屈肌。结果显示，Non-Tr 组和 Step-Tr 组大鼠的急性学习潜力没有差异，而 Stand-Tr 组则表现出学习急性任务的能力下降。对 Stand-Tr 组的进一步研究表明，虽然同侧和对侧后肢的急性学习潜力均显着受损，但未经训练的对侧后肢表现出明显更大的学习缺陷。这些结果表明，不同类型的慢性外周输入可能对学习新运动任务的能力产生重大影响，并证明在缺乏脊髓上连接的情况下脊髓具有依赖于经验的可塑性的潜力。 (c) 2007 Elsevier B.V. 保留所有权利。
Tho effect of two chronic motor training paradigms on the ability of the lumbar spinal cord to perform an acute instrumental learning task was examined in neonatally (postnatal day 5; P5) spinal cord transected (i.e., spinal) rats. At similar to P30, rats began either unipedal hindlimb stand training (Stand-Tr; 20-25 min/day, 5 days/week), or bipedal hindlimb step training (Step-Tr; 20 min/day; 5 days/week) for 7 weeks. Non-trained spinal rats (Non-Tr) served as controls. After 7 weeks all groups were tested on the flexor-biased instrumental learning paradigm. We hypothesized that (1) Step-Tr rats would exhibit an increased capacity to learn the flexor-biased task relative to Non-Tr subjects, as locomotion involves repetitive training of the fibialis anterior (TA), the ankle flexor whose activation is important for successful instrumental learning, and (2) Stand-Tr rats would exhibit a deficit in acute motor learning, as unipedal training activates the ipsilateral ankle extensors, but not flexors. Results showed no differences in acute learning potential between Non-Tr and Step-Tr rats, while the Stand-Tr group showed a reduced capacity to learn the acute task. Further investigation of the Stand-Tr group showed that, while both the ipsilateral and contralateral hindlimbs were significantly impaired in their acute learning potential, the contralateral, untrained hindlimbs exhibited significantly greater learning deficits. These results suggest that different types of chronic peripheral input may have a significant impact on the ability to learn a novel motor task, and demonstrate the potential for experience-dependent plasticity in the spinal cord in the absence of supraspinal connectivity. (c) 2007 Elsevier B.V. All rights reserved.