Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection.
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection.
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DOI：
10.1016/j.bbadis.2008.10.002
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发表时间：
2008-12
影响因子：
6.2
通讯作者：
Taylor, J. Paul
中科院分区：
文献类型：
--
作者：
Nedelsky, Natalia B.;Todd, Peter K.;Taylor, J. Paul
蛋白质降解是一种重要的细胞功能，当失调或受损时，可导致各种疾病状态。两种主要的细胞内蛋白质降解系统是泛素-蛋白酶体系统（UPS）和自噬，自噬是一种涉及将细胞组分递送至溶酶体以进行降解的分解代谢过程。虽然UPS因与神经退行性疾病有关而引起了广泛关注，但自噬和神经退行性疾病之间的重要联系也变得明显。此外，最近的研究揭示了UPS和自噬之间的相互作用，表明这些降解系统之间存在协调和互补的关系，这在细胞应激时变得至关重要。在这里，我们描述了自噬和审查的证据表明，该系统作为一个重要的球员在神经退行性疾病的发病机制。我们讨论了自噬在神经退行性变中的作用，并回顾了疾病模型实验操作所揭示的神经保护功能。最后，我们探讨了自噬和UPS之间的潜在相似之处和联系，强调了它们在预防神经退行性疾病方面的协同作用。
Protein degradation is an essential cellular function that, when dysregulated or impaired, can lead to a wide variety of disease states. The two major intracellular protein degradation systems are the ubiquitin-proteasome system (UPS) and autophagy, a catabolic process that involves delivery of cellular components to the lysosome for degradation. While the UPS has garnered much attention as it relates to neurodegenerative disease, important links between autophagy and neurodegeneration have also become evident. Furthermore, recent studies have revealed interaction between the UPS and autophagy, suggesting a coordinated and complementary relationship between these degradation systems that becomes critical in times of cellular stress. Here we describe autophagy and review evidence implicating this system as an important player in the pathogenesis of neurodegenerative disease. We discuss the role of autophagy in neurodegeneration and review its neuroprotective functions as revealed by experimental manipulation in disease models. Finally, we explore potential parallels and connections between autophagy and the UPS, highlighting their collaborative roles in protecting against neurodegenerative disease.
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影响因子：
5.3
作者：
Finley, KD;Edeen, PT;McKeown, M
通讯作者：
McKeown, M
影响因子：
4.1
作者：
Fuertes, G;De Llano, JJM;Knecht, E
通讯作者：
Knecht, E
p62/SQSTM1形成自噬降解的蛋白质聚集体，并对亨廷顿蛋白诱导的细胞死亡具有保护作用。
影响因子：
7.8
作者：
Bjorkoy, Geir;Lamark, Trond;Brech, Andreas;Outzen, Heidi;Perander, Maria;Overvatn, Aud;Stenmark, Harald;Johansen, Terje
通讯作者：
Johansen, Terje
影响因子：
3.5
作者：
Davies, JE;Sarkar, S;Rubinsztein, DC
通讯作者：
Rubinsztein, DC
影响因子：
4.8
作者：
Berg, TO;Fengsrud, M;Seglen, PO
通讯作者：
Seglen, PO