Is the age of menopause determined in-utero?
Is the age of menopause determined in-utero?
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DOI：
10.1016/s0378-3782(97)00028-5
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发表时间：
1997-09-19
影响因子：
2.5
通讯作者：
Barker, DJP
中科院分区：
文献类型：
--
作者：
Cresswell, JL;Egger, P;Barker, DJP
目的：确定绝经年龄是否与出生时的大小有关。设计：一项对两组妇女的跟踪研究，记录她们出生时的尺寸。地点：英格兰赫特福德郡和谢菲尔德。人口：755名60-71岁的女性出生在赫特福德郡；235名40-42岁的女性出生在谢菲尔德的杰索普医院。主要观察指标：自然绝经年龄或血清卵泡刺激素浓度>25IU/ml。结果：绝经年龄与出生体重无关。然而，在1岁时体重较低的女性中，它发生的年龄较小。这与他们的体重和吸烟习惯无关。在年轻女性群体中，那些早绝经期的人出生时往往很矮，体重指数(出生体重/身长)很高。结论：妊娠晚期生长发育迟缓，导致出生时身材矮小，婴儿期体重增加较少，可能与卵巢原始卵泡数量减少，进而导致更年期提前有关。(C)1997年爱思唯尔爱尔兰科学有限公司。
Objective: To determine whether age at menopause is related to size at birth. Design: A follow-up study of two groups of women whose size at birth was recorded. Setting: Hertfordshire and Sheffield, England. Population: 755 women aged 60-71 years born in Hertfordshire; 235 women aged 40-42 years born in the Jessop Hospital, Sheffield. Main outcome measures: Age at natural menopause or serum follicle stimulating hormone concentration greater than 25 IU/ml. Results: Age at menopause was unrelated to birth weight. However, it occurred at a younger age in women who had low weight at 1 year. This was independent of their body weight and smoking habits. In the population of younger women those who had had an early menopause tended to have been short at birth, with a high ponderal index (birth weight/length(3)). Conclusion: Growth retardation in late gestation, leading to shortness at birth and low weight gain in infancy, may be associated with a reduced number of primordial follicles in the ovary leading in turn to an earlier menopause. (C) 1997 Elsevier Science Ireland Ltd.